Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.49 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19456169 | 0.85 | PARP1 (0.49) | PARP1BRD4TDP1 | |
| SCHEMBL8939924 | 0.83 | PARP1 (0.52) | PARP1TDP1 | |
| SCHEMBL19456258 | 0.83 | TDP1 (0.50) | PARP1BRD4TDP1 | |
| SCHEMBL19456132 | 0.82 | RXFP1 (0.33) | PARP1BRD4 | |
| SCHEMBL19456110 | 0.82 | PARP1 (0.46) | PARP1BRD4TDP1 | |
| SCHEMBL19456161 | 0.82 | PARP1 (0.56) | PARP1BRD4TDP1 | |
| SCHEMBL19456159 | 0.81 | BRD4 (0.39) | PARP1BRD4 | |
| SCHEMBL19456100 | 0.79 | ALDH1A1 (0.46) | PARP1BRD4 | |
| SCHEMBL19456170 | 0.79 | BRD4 (0.55) | PARP1BRD4 | |
| SCHEMBL19456232 | 0.79 | BRD4 (0.54) | PARP1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3440075-B1 | BENZO[B]FURANS AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2020-01-29 | — | — | EP | disclosed |
| WO-2017174620-A1 | BENZO[B]FURANS AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-10-12 | — | — | WO | disclosed |