SCHEMBL1945679

SCHEMBL1945679

C=C(C)C(=O)Oc1ccc(C(=O)O)c(-c2ccccc2)c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ELANE P08246 1/20 0.52
BACE1 P56817 3/20 0.47
KDM4E B2RXH2 4/20 0.44
NPC1 O15118 3/20 0.42
POLB P06746 1/20 0.42
MAPT P10636 2/20 0.40
RAB9A P51151 2/20 0.40
KMT2A Q03164 2/20 0.40
MAPK1 P28482 1/20 0.40
MEN1 O00255 1/20 0.40
GLA P06280 1/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
ALDH1A1 P00352 3/20 0.40
ATM Q13315 1/20 0.40
EPHX1 P07099 1/20 0.39
PTPN1 P18031 1/20 0.39
HDAC7 Q8WUI4 1/20 0.38
GSTP1 P09211 1/20 0.38
LMNA P02545 1/20 0.38
GAA P10253 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrogen Sulfide SCHEMBL27822874 0.85 ELANE (0.55) ELANEBACE1KDM4ENPC1POLB
SCHEMBL10479949 0.85 BACE1 (0.64) ELANEBACE1KDM4ENPC1POLB
SCHEMBL24574531 0.84 ELANE (0.57) ELANEBACE1KDM4ENPC1POLB
SCHEMBL3417185 0.84 ELANE (0.54) ELANEBACE1KDM4ENPC1POLB
SCHEMBL18808103 0.84 EPHX1 (0.54) ELANEBACE1KDM4ENPC1POLB
SCHEMBL6931907 0.82 GAA (0.41) ELANEBACE1KDM4ENPC1POLB
SCHEMBL27689421 0.82 ELANE (0.51) ELANEBACE1KDM4ENPC1POLB
SCHEMBL4862983 0.82 ALDH1A1 (0.59) ELANEKDM4EPOLBMAPTKMT2A
SCHEMBL20998254 0.80 ELANE (0.52) ELANEBACE1KDM4ENPC1POLB
SCHEMBL7705110 0.80 GAA (0.41) ELANEBACE1KDM4EPOLBMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110129622-A1 ALIGNMENT LAYER FOR LCD LACHEZAR KOMITOV (SE) 2011-06-02 US disclosed