Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | JMJD7 | P0C870 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | STAT3 | P40763 | 1/20 | 0.51 |
| ▸ | STAT1 | P42224 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | DHODH | Q02127 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12542531 | 0.93 | ASAH1 (0.51) | HPGDKDM4EMAPTPOLBNPC1 | |
| SCHEMBL12542665 | 0.91 | MKNK2 (0.49) | MAPTRAB9AHTR2CDHODHASAH1 | |
| SCHEMBL12543437 | 0.89 | HTR2C (0.48) | HTR2CDHODHALDH1A1PLK1NEK2 | |
| SCHEMBL12543240 | 0.84 | DHODH (0.50) | HPGDKDM4EMAPTPOLBNPC1 | |
| SCHEMBL12542951 | 0.84 | DHODH (0.48) | HPGDKDM4EMAPTNPC1RAB9A | |
| SCHEMBL12542788 | 0.82 | POLB (0.47) | POLBDHODHMEN1KMT2APLK1 | |
| SCHEMBL12543085 | 0.82 | POLB (0.47) | POLBDHODHMEN1KMT2APLK1 | |
| SCHEMBL12542542 | 0.81 | PLK1 (0.51) | MAPTRAB9ADHODHPLK1NEK2 | |
| SCHEMBL1948153 | 0.81 | DHODH (0.58) | HPGDKDM4EMAPTPOLBNPC1 | |
| SCHEMBL12542421 | 0.80 | DHODH (0.71) | HPGDKDM4EMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8703811-B2 | Small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase | GENZYME CORPORATION (US) | 2014-04-22 | — | — | US | disclosed |
| US-8703811-B2 | Small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase | GENZYME CORPORATION (US) | 2014-04-22 | — | — | US | disclosed |
| US-8703811-B2 | Small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase | GENZYME CORPORATION (US) | 2014-04-22 | — | — | US | disclosed |
| US-20110130381-A1 | SMALL MOLECULE INHIBITORS OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE | GENZYME CORPORATION | 2011-06-02 | — | — | US | disclosed |
| US-20110130381-A1 | SMALL MOLECULE INHIBITORS OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE | GENZYME CORPORATION | 2011-06-02 | — | — | US | disclosed |
| US-20110130381-A1 | SMALL MOLECULE INHIBITORS OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE | GENZYME CORPORATION | 2011-06-02 | — | — | US | disclosed |
| WO-2009137081-A2 | SMALL MOLECULE INHIBITORS OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2009-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110130381-A1 | SMALL MOLECULE INHIBITORS OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE | DHODH, DLD, MDH1 | HPGD 105/4885KDM4E 1908/4885MAPT 2356/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.