Sugi Predict

Sugi Predict / Targets / MDH1

MDH1

Malate dehydrogenase, cytoplasmic · P40925 · MDH1 on Sugi Atlas →

7,888 patent compounds predicted against MDH1, 5,270 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL446031 SCHEMBL446031 0.45 13/20
SCHEMBL1836425 SCHEMBL1836425 0.47 11/20
SCHEMBL338553 SCHEMBL338553 0.47 11/20
SCHEMBL4295580 SCHEMBL4295580 0.80 10/20
SCHEMBL1064180 SCHEMBL1064180 0.49 10/20
SCHEMBL4899225 SCHEMBL4899225 0.44 10/20
SCHEMBL988235 SCHEMBL988235 0.42 10/20
SCHEMBL4619376 SCHEMBL4619376 0.42 10/20
SCHEMBL4291874 SCHEMBL4291874 0.44 9/20
SCHEMBL2108184 SCHEMBL2108184 0.44 9/20
1,4-Butanediol 1,4-Butanediol (SCHEMBL1592411) 0.42 9/20
SCHEMBL338551 SCHEMBL338551 0.40 9/20
SCHEMBL1223543 SCHEMBL1223543 0.54 8/20
SCHEMBL2600376 SCHEMBL2600376 0.46 8/20
SCHEMBL821797 SCHEMBL821797 0.43 7/20
SCHEMBL200171 SCHEMBL200171 0.39 7/20
SCHEMBL4580070 SCHEMBL4580070 0.37 7/20
SCHEMBL3299387 SCHEMBL3299387 0.35 7/20
SCHEMBL411772 SCHEMBL411772 0.44 6/20
SCHEMBL480668 SCHEMBL480668 0.44 6/20

Clinical trials — most relevant to MDH1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Glutamate for Metabolic Intervention in Coronary Surgery PHASE3COMPLETED
Trial of Dichloroacetate in Pyruvate Dehydrogenase Complex Deficiency: PHASE3ACTIVE_NOT_RECRUITING
Phase III Trial of Coenzyme Q10 in Mitochondrial Disease PHASE3COMPLETED
Acetylcarnitine and Insulin Sensitivity PHASE2COMPLETED
Overcoming Primary Resistance to Immunotherapy in Metastatic Melanoma PHASE2COMPLETED
Atorvastatin, L-Carnitine and Non-Alcoholic Steatohepatitis PHASE2UNKNOWN
Multi-omics Study in Citrin Deficiency nanACTIVE_NOT_RECRUITING
GDF-15 as a Biomarker for Mitochondrial Disease nanCOMPLETED
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine nanCOMPLETED
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC) nanRECRUITING
Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence nanNOT_YET_RECRUITING
Tissue Sample Study for Mitochondrial Disorders nanENROLLING_BY_INVITATION
Fatty Acid Oxidation Defects and Insulin Sensitivity nanCOMPLETED
MITOMICS : a Multi-OMICS Approach for the Diagnosis of Mitochondrial Diseases nanRECRUITING
Mitochondrial Dysfunction in Phelan-McDermid Syndrome nanCOMPLETED
Identification of New Candidate Genes in Patients With Mitochondrial Disease by High Resolution Chromosome Analysis on DNA Chip nanCOMPLETED
Calf Muscle Strength in Mitochondrial Diseases nanCOMPLETED
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes nanNOT_YET_RECRUITING
Survey on Supplement Use in Mitochondrial Disease nanCOMPLETED
Triheptanoin (UX007) to Treat Citrate Transporter Deficiency nanNO_LONGER_AVAILABLE
Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide nanRECRUITING
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia nanRECRUITING
Natural History in Primary Mitochondrial Myopathies nanRECRUITING
A Study Into the Underlying Biochemical Pathways Involved in Parkinson's Disease, Such as Mitochondrial (Cellular Powerhouse) Dysfunction nanCOMPLETED
ALDH2 Single Nucleotide Polymorphisms and Prognosis of Esophageal Cancer Patients nanRECRUITING
MItochondrial Diabetes LOw Carb- Diet Study nanCOMPLETED
Natural History Study of Mitochondrial Myopathy nanRECRUITING
Gastrointestinal Dysfunction in Children Affected With Mitochondrial Disorders nanCOMPLETED
Drug Repurposing for Mitochondrial Disorders Using iPSCs Derived Neural Cells nanRECRUITING
Natural History Study of FDXR Mutation-related Mitochondriopathy nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a MDH1 binder may also engage these)

ProteinNameSimilarity
P14152 — 1.000 P14152 →
Q3T145 — 1.000 Q3T145 →
P11708 — 1.000 P11708 →
O88989 — 1.000 O88989 →
Q6PAB3 — 1.000 Q6PAB3 →
Q5ZME2 — 1.000 Q5ZME2 →
Q7YRU4 — 1.000 Q7YRU4 →
Q7XDC8 — 0.998 Q7XDC8 →
P93819 — 0.998 P93819 →
P57106 — 0.998 P57106 →
F1C7I4 — 0.998 F1C7I4 →
Q54VM2 — 0.997 Q54VM2 →
Q6DIY9 — 0.996 Q6DIY9 →
Q04820 — 0.996 Q04820 →
O24047 — 0.996 O24047 →
O48905 — 0.996 O48905 →
Q21K60 — 0.995 Q21K60 →
A4SWW0 — 0.995 A4SWW0 →
B2JQD2 — 0.995 B2JQD2 →
Q21XH1 — 0.994 Q21XH1 →
P61975 — 0.994 P61975 →
Q5H496 — 0.994 Q5H496 →
Q4URH2 — 0.994 Q4URH2 →
Q8PC25 — 0.994 Q8PC25 →
Q8F4A2 — 0.994 Q8F4A2 →
B0SF41 — 0.993 B0SF41 →
Q9UAV5 — 0.993 Q9UAV5 →
A2SHT9 — 0.993 A2SHT9 →
Q08062 — 0.993 Q08062 →
Q2P736 — 0.993 Q2P736 →