Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB3 | Q16875 | 4/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.58 |
| ▸ | GHSR | Q92847 | 3/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | MLNR | O43193 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CNKSR1 | Q969H4 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1948202 | 0.86 | MAPT (0.68) | PFKFB3MAPTHTTSMN1; SMN2NPSR1 | |
| SCHEMBL1946248 | 0.83 | PTGES2 (0.55) | PFKFB3MAPTHTTSMN1; SMN2NPSR1 | |
| SCHEMBL788488 | 0.78 | PFKFB3 (1.00) | PFKFB3MAPTGHSRRXFP1MLNR | |
| SCHEMBL12563556 | 0.77 | HSD11B1 (0.80) | PFKFB3MAPTHTTSMN1; SMN2NPSR1 | |
| SCHEMBL12955622 | 0.77 | PARP1 (0.61) | PFKFB3GHSR | |
| SCHEMBL1947196 | 0.77 | HSD11B1 (0.63) | MAPTHTTSMN1; SMN2NPSR1HSD11B1 | |
| SCHEMBL1948063 | 0.77 | HSD11B1 (0.69) | PFKFB3MAPTHTTSMN1; SMN2NPSR1 | |
| SCHEMBL1944991 | 0.76 | SMN1; SMN2 (0.74) | MAPTHTTSMN1; SMN2NPSR1HSD11B1 | |
| SCHEMBL1947915 | 0.76 | MAPT (0.72) | MAPTHTTSMN1; SMN2NPSR1HSD11B1 | |
| SCHEMBL1946616 | 0.75 | MAPT (0.64) | MAPTHTTSMN1; SMN2NPSR1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110130426-A1 | Novel Sulphonamide Derivatives as Glucocorticoid Receptor Modulators for the Treatment of Inflammatory Diseases | ASTRAZENECA AB (SE) | 2011-06-02 | — | — | US | disclosed |
| US-20110130426-A1 | Novel Sulphonamide Derivatives as Glucocorticoid Receptor Modulators for the Treatment of Inflammatory Diseases | ASTRAZENECA AB (SE) | 2011-06-02 | — | — | US | disclosed |
| US-20110130426-A1 | Novel Sulphonamide Derivatives as Glucocorticoid Receptor Modulators for the Treatment of Inflammatory Diseases | ASTRAZENECA AB (SE) | 2011-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110130426-A1 | Novel Sulphonamide Derivatives as Glucocorticoid Receptor Modulators for the Treatment of Inflammatory Diseases | NR3C1, NR3C2, NR5A1 | PFKFB3 3119/4885MAPT 3552/4885HTT 3259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.