Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | DHODH | Q02127 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12543452 | 0.80 | DHODH (0.72) | HRH3TP53DHODHCYP2D6KCNH2 | |
| SCHEMBL1948459 | 0.77 | DHODH (0.49) | HRH3TP53DHODHCYP2D6KCNH2 | |
| SCHEMBL12543821 | 0.71 | CYP2D6 (0.68) | TP53DHODHCYP2D6THRBKCNH2 | |
| SCHEMBL14000448 | 0.70 | HRH3 (0.65) | HRH3TP53THRBKCNH2MAPT | |
| SCHEMBL3670248 | 0.70 | HRH3 (0.65) | HRH3TP53THRBKCNH2MAPT | |
| SCHEMBL3670242 | 0.70 | HRH3 (0.65) | HRH3TP53THRBKCNH2MAPT | |
| SCHEMBL12543861 | 0.70 | CYP2D6 (0.67) | TP53DHODHCYP2D6THRBKCNH2 | |
| SCHEMBL12543147 | 0.70 | CYP2D6 (0.59) | TP53DHODHCYP2D6KCNH2MAPT | |
| SCHEMBL12543121 | 0.70 | CYP2D6 (0.72) | TP53DHODHCYP2D6THRBKCNH2 | |
| SCHEMBL12543233 | 0.69 | DHODH (0.85) | TP53DHODHCYP2D6KCNH2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8703811-B2 | Small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase | GENZYME CORPORATION (US) | 2014-04-22 | — | — | US | disclosed |
| US-8703811-B2 | Small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase | GENZYME CORPORATION (US) | 2014-04-22 | — | — | US | disclosed |
| US-8703811-B2 | Small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase | GENZYME CORPORATION (US) | 2014-04-22 | — | — | US | disclosed |
| US-20110130381-A1 | SMALL MOLECULE INHIBITORS OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE | GENZYME CORPORATION | 2011-06-02 | — | — | US | disclosed |
| US-20110130381-A1 | SMALL MOLECULE INHIBITORS OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE | GENZYME CORPORATION | 2011-06-02 | — | — | US | disclosed |
| US-20110130381-A1 | SMALL MOLECULE INHIBITORS OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE | GENZYME CORPORATION | 2011-06-02 | — | — | US | disclosed |
| WO-2009137081-A2 | SMALL MOLECULE INHIBITORS OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2009-11-12 | — | — | WO | disclosed |
| WO-2009137081-A2 | SMALL MOLECULE INHIBITORS OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2009-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110130381-A1 | SMALL MOLECULE INHIBITORS OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE | DHODH, DLD, MDH1 | HRH3 1161/4885TP53 1255/4885DHODH 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.