Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.37 |
| ▸ | HTR2A | P28223 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | ESRRA | P11474 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15731295 | 0.76 | CFTR (0.44) | TRPV1KCNH2SLC6A4ALDH1A1HSD17B10 | |
| SCHEMBL5685349 | 0.73 | CASP1 (0.45) | HTR2AHSD17B10KMT2AESRRACYP3A4 | |
| SCHEMBL19465218 | 0.73 | TAAR1 (0.35) | SLC6A4 | |
| SCHEMBL15716429 | 0.72 | TRPV1 (0.39) | TRPV1KCNH2SLC6A4ALDH1A1HSD17B10 | |
| SCHEMBL3787060 | 0.70 | SLC6A4 (0.44) | KCNH2SLC6A4HTR2ACYP2D6MRGPRX4 | |
| SCHEMBL11959864 | 0.68 | TAAR1 (0.52) | KCNH2SLC6A4KMT2ACYP1A2CYP3A4 | |
| SCHEMBL6681553 | 0.67 | PPARG (0.44) | KCNH2SLC6A4HTR2APPARGPPARD | |
| SCHEMBL18608786 | 0.67 | KDM4E (0.45) | SLC6A4ALDH1A1HSD17B10HTTKDM4E | |
| SCHEMBL10233689 | 0.67 | KDM4E (0.54) | TRPV1ALDH1A1HSD17B10HTTKDM4E | |
| SCHEMBL22265222 | 0.66 | ANO1 (0.43) | KCNH2SLC6A4HTR2AKMT2ACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9790210-B2 | N-(monocyclic aryl),N'-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2017-10-17 | — | — | US | disclosed |