Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | NQO2 | P16083 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | ESRRA | P11474 | 4/20 | 0.39 |
| ▸ | AR | P10275 | 2/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.38 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.38 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10451549 | 0.83 | MEN1 (0.53) | CASP1HSD17B10L3MBTL1RAB9AMEN1 | |
| SCHEMBL2379685 | 0.77 | ALDH1A1 (0.56) | L3MBTL1RAB9AESRRAAR | |
| SCHEMBL5656320 | 0.77 | AR (0.50) | ESRRAAR | |
| SCHEMBL3787060 | 0.76 | SLC6A4 (0.44) | L3MBTL1MAPTHTR2A | |
| SCHEMBL531610 | 0.75 | L3MBTL1 (0.45) | HSD17B10L3MBTL1RAB9AMEN1ALOX15 | |
| Hydrogen Sulfide SCHEMBL28045417 | 0.74 | CFTR (0.57) | HSD17B10RAB9AMEN1KMT2AMAPT | |
| SCHEMBL169247 | 0.74 | GAA (0.55) | L3MBTL1RAB9AMEN1ALOX15MAPK1 | |
| SCHEMBL19465243 | 0.73 | TRPV1 (0.37) | HSD17B10MEN1KMT2AHTR2AESRRA | |
| SCHEMBL28407737 | 0.72 | L3MBTL1 (0.45) | HSD17B10L3MBTL1RAB9AMEN1ALOX15 | |
| SCHEMBL2669936 | 0.72 | L3MBTL1 (0.45) | HSD17B10L3MBTL1RAB9AMEN1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170362186-A1 | Salts of a dihydroquinazoline derivative | AICURIS GMBH & CO. KG (DE) | 2017-12-21 | — | — | US | disclosed |
| US-9637459-B2 | Sodium and calcium salts of dihydroquinazoline derivative and use thereof as antiviral agents | AICURIS GMBH & CO KG. (DE) | 2017-05-02 | — | — | US | disclosed |
| US-20170114026-A1 | Salts of a dihydroquinazoline derivative | AICURIS GMBH & CO. KG (DE) | 2017-04-27 | — | — | US | disclosed |
| US-9512085-B2 | Salts of a dihydroquinazoline derivative | AICURIS GMBH & CO. KG (DE) | 2016-12-06 | — | — | US | disclosed |
| US-20150133461-A1 | PHARMACEUTICAL COMPOSITION CONTAINING AN ANTIVIRALLY ACTIVE DIHYDROQUINAZOLINE DERIVATIVE | AICURIS GMBH & CO. KG (DE) | 2015-05-14 | — | — | US | disclosed |
| US-20150045371-A1 | Salts of a dihydroquinazoline derivative | AICURIS GMBH & CO. KG (DE) | 2015-02-12 | — | — | US | disclosed |
| US-20150038514-A1 | SODIUM AND CALCIUM SALTS OF DIHYDROQUINAZOLINE DERIVATIVE AND USE THEREOF AS ANTIVIRAL AGENTS | AIC246 AG & CO. KG (DE) | 2015-02-05 | — | — | US | disclosed |
| US-8816075-B2 | Process for the preparation of dihydroquinazolines | AICURIS GMBH & CO. KG (DE) | 2014-08-26 | — | — | US | disclosed |
| US-20130066073-A1 | PROCESS FOR THE PREPARATION OF DIHYDROQUINAZOLINES | AIC246 AG & CO. KG (DE) | 2013-03-14 | — | — | US | disclosed |
| US-8372972-B2 | Process for the preparation of dihydroquinazolines | AICURIS GMBH & CO. KG (DE) | 2013-02-12 | — | — | US | disclosed |
| US-20120130072-A1 | PROCESS FOR THE PREPARATION OF DIHYDROQUINAZOLINES | AICURIS GMBH & CO. KG (DE) | 2012-05-24 | — | — | US | disclosed |
| EP-1625129-A1 | HETEROCYCLYL-SUBSTITUTED DIHYDROQUINAZOLINES AND USE THEREOF AS AN ANTIVIRAL AGENT | Bayer HealthCare AG (DE) | 2006-02-15 | — | — | EP | disclosed |
| EP-1622880-A1 | SUBSTITUTED DIHYDROCHINAZOLINES HAVING ANTIVIRAL PROPERTIES | Bayer HealthCare AG (DE) | 2006-02-08 | — | — | EP | disclosed |
| WO-2004099212-A1 | HETEROCYCLYL-SUBSTITUTED DIHYDROQUINAZOLINES AND USE THEREOF AS AN ANTIVIRAL AGENT | BAYER HEALTHCARE AG (DE) | 2004-11-18 | — | — | WO | disclosed |
| WO-2004096778-A1 | SUBSTITUTED DIHYDROCHINAZOLINES HAVING ANTIVIRAL PROPERTIES | BAYER HEALTHCARE AG (DE) | 2004-11-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130066073-A1 | PROCESS FOR THE PREPARATION OF DIHYDROQUINAZOLINES | QDPR, DHPS, DHX15 | CASP1 2987/4885HSD17B10 2232/4885L3MBTL1 4877/4885 |
| US-20170114026-A1 | Salts of a dihydroquinazoline derivative | BAD, VHL, EIF2AK2 | CASP1 262/4885HSD17B10 3567/4885L3MBTL1 2656/4885 |
| US-20150038514-A1 | SODIUM AND CALCIUM SALTS OF DIHYDROQUINAZOLINE DERIVATIVE AND USE THEREOF AS ANTIVIRAL AGENTS | CACNA1I, CACNA1F, CACNA1S | CASP1 481/4885HSD17B10 4357/4885L3MBTL1 4340/4885 |
| US-20150133461-A1 | PHARMACEUTICAL COMPOSITION CONTAINING AN ANTIVIRALLY ACTIVE DIHYDROQUINAZOLINE DERIVATIVE | RPL5, EIF2AK2, RPL35 | CASP1 2355/4885HSD17B10 3916/4885L3MBTL1 4476/4885 |
| US-20170362186-A1 | Salts of a dihydroquinazoline derivative | BAD, CHUK, EIF2AK2 | CASP1 479/4885HSD17B10 4026/4885L3MBTL1 2852/4885 |
| US-20120130072-A1 | PROCESS FOR THE PREPARATION OF DIHYDROQUINAZOLINES | QDPR, DHPS, DHX15 | CASP1 2987/4885HSD17B10 2232/4885L3MBTL1 4877/4885 |
| US-20150045371-A1 | Salts of a dihydroquinazoline derivative | BAD, CHUK, EIF2AK2 | CASP1 479/4885HSD17B10 4026/4885L3MBTL1 2852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.