SCHEMBL19465263

SCHEMBL19465263

CCC(C)(CC)c1cc(C)c(-c2cc(C(O)(C(F)(F)F)C(F)(F)F)c(N3C(=O)c4ccc(Oc5ccc6c(c5)C(=O)N(C(C)(C)CC)C6=O)cc4C3=O)cc2C)cc1C(O)(C(F)(F)F)C(F)(F)F

nearest known ligand 0.33

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.33
MEN1 O00255 3/20 0.33
KMT2A Q03164 3/20 0.33
LPAR1 Q92633 1/20 0.33
LPAR3 Q9UBY5 1/20 0.33
GAA P10253 1/20 0.33
PKM P14618 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
BRD4 O60885 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
KDM4E B2RXH2 2/20 0.31
HTT P42858 1/20 0.31
POLB P06746 1/20 0.31
MAPK1 P28482 1/20 0.31
HSD17B10 Q99714 1/20 0.31
PDCD1 Q15116 1/20 0.30
CD274 Q9NZQ7 1/20 0.30
ESR1 P03372 1/20 0.30
ESR2 Q92731 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19465259 0.85 ESR1 (0.32) ESR1ESR2
SCHEMBL15745685 0.73 ALDH1A1 (0.37) ALDH1A1MEN1KMT2ALPAR1LPAR3
SCHEMBL24418089 0.72 TDP1 (0.50) ALDH1A1MEN1KMT2ALPAR1LPAR3
SCHEMBL19465261 0.71
SCHEMBL15746934 0.68 APEX1 (0.37) ALDH1A1MEN1KMT2APKMNPSR1
SCHEMBL13220607 0.67 NR1H2 (0.41) ALDH1A1MEN1KMT2ALPAR1LPAR3
SCHEMBL15746897 0.67 RORA (0.34)
SCHEMBL15579514 0.66 BRD4 (0.50) ALDH1A1MEN1KMT2APKMNPSR1
SCHEMBL23486893 0.64 TDP1 (0.49) ALDH1A1MEN1KMT2ALPAR1LPAR3
SCHEMBL19423932 0.64 MEN1 (0.44) ALDH1A1MEN1KMT2ALPAR1LPAR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9793483-B2 Hexafluoroisopropanol group-containing diamine, polyimide and polyamide using same, cyclized product thereof, and method for producing same CENTRAL GLASS COMPANY, LIMITED (JP) 2017-10-17 US disclosed