Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA1 | Q09470 | 4/20 | 0.70 |
| ▸ | KCNAB1 | Q14722 | 4/20 | 0.70 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | NAMPT | P43490 | 2/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12540372 | 0.89 | KCNA1 (0.66) | KCNA1KCNAB1KMT2AMEN1NPC1 | |
| SCHEMBL1945844 | 0.83 | KCNA1 (0.86) | KCNA1KCNAB1CA12CA1CA2 | |
| SCHEMBL1949184 | 0.79 | KCNA1 (0.88) | KCNA1KCNAB1NAMPTKMT2AMEN1 | |
| SCHEMBL27196377 | 0.75 | POLB (0.70) | KMT2AMEN1NPC1TDP1KDM4E | |
| SCHEMBL6392375 | 0.75 | KMT2A (0.61) | KCNA1KCNAB1NAMPTKMT2AMEN1 | |
| SCHEMBL1028559 | 0.73 | KMT2A (0.59) | NAMPTKMT2AMEN1NPC1TDP1 | |
| SCHEMBL1945684 | 0.73 | KCNA1 (0.80) | KCNA1KCNAB1CA12CA1CA2 | |
| SCHEMBL5800630 | 0.73 | KDM4E (0.69) | KMT2AMEN1KDM4ENPSR1HRH3 | |
| SCHEMBL4197501 | 0.73 | KDM4E (0.69) | KMT2AMEN1KDM4ENPSR1HRH3 | |
| SCHEMBL20804368 | 0.73 | NPC1 (0.65) | CA12CA1CA2CA9GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110130383-A1 | Use of Ion Channel Modulators in the Prophylaxis and Treatment of Inflammatory and Immunological Diseases | LECTUS THERAPEUTICS LIMITED (GB) | 2011-06-02 | — | — | US | claimed |
| US-20110130383-A1 | Use of Ion Channel Modulators in the Prophylaxis and Treatment of Inflammatory and Immunological Diseases | LECTUS THERAPEUTICS LIMITED (GB) | 2011-06-02 | — | — | US | disclosed |
| WO-2008038051-A2 | USE OF ION CHANNEL MODULATORS IN THE PROPHYLAXIS AND TREATMENT OF INFLAMMATORY AND IMMUNOLOGICAL DISEASES | LECTUS THERAPEUTICS LIMITED (GB) | 2008-04-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110130383-A1 | Use of Ion Channel Modulators in the Prophylaxis and Treatment of Inflammatory and Immunological Diseases | HCAR2, HCAR1, SCN7A | KCNA1 167/4885KCNAB1 98/4885CA12 1814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.