Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 5/20 | 0.42 |
| ▸ | PLA2G4A | P47712 | 5/20 | 0.42 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | NQO1 | P15559 | 1/20 | 0.38 |
| ▸ | TSPO | P30536 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | TNKS | O95271 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17637710 | 0.95 | PLA2G2A (0.42) | PLA2G2APLA2G4APLA2G10NPSR1RXFP1 | |
| SCHEMBL19472141 | 0.93 | KDM4E (0.41) | PLA2G2APLA2G4APLA2G10NPSR1RXFP1 | |
| SCHEMBL19472197 | 0.92 | NPSR1 (0.45) | PLA2G2APLA2G4ANPSR1RXFP1TSPO | |
| SCHEMBL19472195 | 0.92 | NPC1 (0.45) | PLA2G2APLA2G4APLA2G10NPSR1RXFP1 | |
| SCHEMBL19472139 | 0.91 | NPSR1 (0.40) | PLA2G2APLA2G4APLA2G10NPSR1RXFP1 | |
| SCHEMBL17637842 | 0.91 | NPSR1 (0.43) | PLA2G2APLA2G4ANPSR1RXFP1CA9 | |
| SCHEMBL17637885 | 0.91 | L3MBTL1 (0.46) | PLA2G2APLA2G4APLA2G10NPSR1RXFP1 | |
| SCHEMBL17637780 | 0.91 | NPSR1 (0.42) | PLA2G2APLA2G4APLA2G10NPSR1RXFP1 | |
| SCHEMBL19472140 | 0.91 | NPSR1 (0.41) | PLA2G2APLA2G4ANPSR1RXFP1TSPO | |
| SCHEMBL19472202 | 0.91 | L3MBTL1 (0.43) | PLA2G2APLA2G4APLA2G10NPSR1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3197887-B1 | HETEROCYCLIC COMPOUNDS WITH BENZO[C]COUMARIN-STRUCTURES | MERCK PATENT GMBH (DE) | 2020-09-23 | — | — | EP | disclosed |
| US-10377766-B2 | Heterocyclic compounds with benzo(c)coumarin-structures | MERCK PATENT GMBH (DE) | 2019-08-13 | — | — | US | disclosed |
| US-20170298077-A1 | HETEROCYCLIC COMPOUNDS WITH BENZO(C)COUMARIN-STRUCTURES | MERCK PATENT GMBH (DE) | 2017-10-19 | — | — | US | disclosed |
| US-20170298077-A1 | HETEROCYCLIC COMPOUNDS WITH BENZO(C)COUMARIN-STRUCTURES | MERCK PATENT GMBH (DE) | 2017-10-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170298077-A1 | HETEROCYCLIC COMPOUNDS WITH BENZO(C)COUMARIN-STRUCTURES | NISCH, SIRT3, NQO1 | PLA2G2A 4862/4885PLA2G4A 4861/4885PLA2G10 4856/4885 |
| US-10377766-B2 | Heterocyclic compounds with benzo(c)coumarin-structures | NISCH, SIRT3, NQO1 | PLA2G2A 4862/4885PLA2G4A 4861/4885PLA2G10 4856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.