Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 4/20 | 0.48 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.46 |
| ▸ | PTPRC | P08575 | 1/20 | 0.45 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | PTPRB | P23467 | 1/20 | 0.45 |
| ▸ | PTPRE | P23469 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | NPC1 | O15118 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19475104 | 0.81 | CFTR (0.65) | ANO1PTPRCPTPN2PTPN1PTPRB | |
| SCHEMBL6250301 | 0.79 | MEN1 (0.56) | POLBALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2643514 | 0.75 | ALDH1A1 (0.52) | MAPK10POLBALDH1A1NPC1RAB9A | |
| SCHEMBL19475093 | 0.75 | ALDH1A1 (0.52) | ANO1ALDH1A1SMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL20915159 | 0.74 | ALDH1A1 (0.60) | POLBALDH1A1SMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL618553 | 0.74 | ALDH1A1 (0.59) | MAPK10POLBALDH1A1NPC1RAB9A | |
| SCHEMBL2643860 | 0.71 | GCGR (0.49) | MAPK10POLBALDH1A1NPC1RAB9A | |
| SCHEMBL5467114 | 0.66 | CFTR (0.64) | ANO1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL621181 | 0.66 | BPTF (0.59) | POLBALDH1A1SMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL3279132 | 0.65 | MAPK10 (0.77) | MAPK10POLBALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10647725-B2 | Anti-infective 2-aminothiophenes | THE UNIVERSITY OF TOLEDO (US) | 2020-05-12 | — | — | US | disclosed |
| US-10647725-B2 | Anti-infective 2-aminothiophenes | THE UNIVERSITY OF TOLEDO (US) | 2020-05-12 | — | — | US | disclosed |
| US-20190119296-A1 | Anti-Infective 2-Aminothiophenes | THE UNIVERSITY OF TOLEDO (US) | 2019-04-25 | — | — | US | disclosed |
| US-20190119296-A1 | Anti-Infective 2-Aminothiophenes | THE UNIVERSITY OF TOLEDO (US) | 2019-04-25 | — | — | US | disclosed |
| WO-2017184947-A1 | ANTI-INFECTIVE 2-AMINOTHIOPHENES | THE UNIVERSITY OF TOLEDO (US) | 2017-10-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190119296-A1 | Anti-Infective 2-Aminothiophenes | TST, ABAT, TPMT | MAPK10 3880/4885ANO1 3263/4885PTPRC 2522/4885 |
| US-10647725-B2 | Anti-infective 2-aminothiophenes | TST, ABAT, TPMT | MAPK10 3880/4885ANO1 3263/4885PTPRC 2522/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.