Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.70 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.63 |
| ▸ | DHODH | Q02127 | 7/20 | 0.59 |
| ▸ | EPRS1 | P07814 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | PTGES | O14684 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8619265 | 0.87 | KDM4E (0.81) | KDM4EALDH1A1PDE10AHSD17B10DHODH | |
| SCHEMBL19475436 | 0.84 | DHODH (0.64) | KDM4EALDH1A1PDE10AHSD17B10DHODH | |
| SCHEMBL19475477 | 0.84 | HIF1A (0.68) | KDM4EALDH1A1PDE10AHSD17B10DHODH | |
| SCHEMBL16921273 | 0.83 | DHODH (0.80) | KDM4EALDH1A1PDE10ADHODHEPRS1 | |
| SCHEMBL8240327 | 0.82 | POLB (0.66) | KDM4EALDH1A1PDE10AHSD17B10DHODH | |
| SCHEMBL4017739 | 0.80 | DHODH (0.80) | KDM4EALDH1A1PDE10AHSD17B10DHODH | |
| SCHEMBL29788466 | 0.80 | DHODH (0.80) | KDM4EALDH1A1PDE10AHSD17B10DHODH | |
| SCHEMBL8321335 | 0.78 | ALDH1A1 (0.79) | KDM4EALDH1A1PDE10AHSD17B10DHODH | |
| SCHEMBL1898810 | 0.77 | KDM4E (1.00) | KDM4EALDH1A1PDE10AHSD17B10DHODH | |
| SCHEMBL3457907 | 0.77 | ALDH1A1 (0.77) | KDM4EALDH1A1PDE10AHSD17B10DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017184547-A1 | QUINOLINE COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | NEW YORK UNIVERSITY (US) | 2017-10-26 | — | — | WO | disclosed |