Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.68 |
| ▸ | PTGES | O14684 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.68 |
| ▸ | HPGD | P15428 | 1/20 | 0.68 |
| ▸ | CASP7 | P55210 | 1/20 | 0.68 |
| ▸ | DHODH | Q02127 | 8/20 | 0.62 |
| ▸ | EPRS1 | P07814 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | EIF4A1 | P60842 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19475331 | 0.90 | ALDH1A1 (0.84) | HIF1AHSD17B10PTGESALDH1A1ALOX5 | |
| SCHEMBL1901263 | 0.87 | KDM4E (0.72) | HIF1AHSD17B10PTGESALDH1A1ALOX5 | |
| SCHEMBL31590457 | 0.86 | PTGES (0.68) | HIF1AHSD17B10PTGESALDH1A1ALOX5 | |
| SCHEMBL19475297 | 0.86 | PTGES (0.60) | HIF1AHSD17B10PTGESALDH1A1ALOX5 | |
| SCHEMBL19475436 | 0.84 | DHODH (0.64) | HIF1AHSD17B10ALDH1A1DHODHEPRS1 | |
| SCHEMBL19475461 | 0.84 | KDM4E (0.70) | HIF1AHSD17B10PTGESALDH1A1ALOX5 | |
| SCHEMBL16921273 | 0.83 | DHODH (0.80) | ALDH1A1HPGDDHODHEPRS1KDM4E | |
| SCHEMBL31590856 | 0.82 | PTGES (0.61) | HIF1AHSD17B10PTGESALDH1A1ALOX5 | |
| SCHEMBL14286200 | 0.81 | HSD17B10 (1.00) | HIF1AHSD17B10PTGESALDH1A1ALOX5 | |
| SCHEMBL5529524 | 0.81 | HSD17B10 (0.94) | HIF1AHSD17B10PTGESALDH1A1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017184547-A1 | QUINOLINE COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | NEW YORK UNIVERSITY (US) | 2017-10-26 | — | — | WO | disclosed |