Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.37 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19507750 | 0.93 | MAPT (0.41) | FYNEGFRDYRK1APIK3R1PIK3CA | |
| SCHEMBL19507751 | 0.91 | MKNK1 (0.38) | FYNEGFRCLK4MEN1KMT2A | |
| SCHEMBL19507678 | 0.91 | CLK4 (0.41) | FYNDYRK1APIK3R1PIK3CACLK4 | |
| SCHEMBL19507771 | 0.89 | MKNK1 (0.40) | FYNEGFRCLK4MEN1KMT2A | |
| SCHEMBL19507728 | 0.88 | LRRK2 (0.37) | FYNDYRK1APIK3R1PIK3CAMAPK1 | |
| SCHEMBL19507752 | 0.87 | FYN (0.35) | FYNDYRK1APIK3R1PIK3CAMEN1 | |
| SCHEMBL19507682 | 0.87 | MAPT (0.41) | EGFRMEN1KMT2ATP53MAPK1 | |
| SCHEMBL12067067 | 0.84 | TNNI3K (0.55) | — | |
| SCHEMBL19507744 | 0.81 | KMT2A (0.41) | FYNPIK3R1PIK3CAMEN1KMT2A | |
| SCHEMBL19507649 | 0.80 | MAPK8 (0.45) | EGFRMEN1KMT2AMKNK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190119284-A1 | ErbB Inhibitors and Uses Thereof | THE SCRIPPS RESEARCH INSTITUTE | 2019-04-25 | — | — | US | disclosed |
| US-20190119284-A1 | ErbB Inhibitors and Uses Thereof | THE SCRIPPS RESEARCH INSTITUTE | 2019-04-25 | — | — | US | disclosed |
| WO-2017184775-A1 | ERBB INHIBITORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-10-26 | — | — | WO | disclosed |
| WO-2017184775-A1 | ERBB INHIBITORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-10-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190119284-A1 | ErbB Inhibitors and Uses Thereof | ERBB3, ERBB2, EGFR | FYN 227/4885EGFR 3/4885DYRK1A 326/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.