Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.34 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 5/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19475696 | 0.87 | FYN (0.40) | FYNHSP90AA1HSP90AB1MEN1KMT2A | |
| SCHEMBL19507750 | 0.85 | MAPT (0.41) | FYNRAF1BRAFMEN1KMT2A | |
| SCHEMBL19507682 | 0.84 | MAPT (0.41) | MEN1KMT2AALDH1A1MAPTKDM4E | |
| SCHEMBL19507726 | 0.83 | MKNK1 (0.37) | RIPK2RIPK3RAF1BRAFMEN1 | |
| SCHEMBL19508350 | 0.83 | MAPT (0.31) | MEN1KMT2AALDH1A1MAPTMAPK1 | |
| SCHEMBL19507678 | 0.82 | CLK4 (0.41) | FYNRAF1BRAFMEN1KMT2A | |
| SCHEMBL19507728 | 0.80 | LRRK2 (0.37) | FYNMAPTDYRK1AMKNK1PIK3R1 | |
| SCHEMBL19507751 | 0.79 | MKNK1 (0.38) | FYNRAF1BRAFMEN1KMT2A | |
| SCHEMBL19507771 | 0.77 | MKNK1 (0.40) | FYNRAF1BRAFMEN1KMT2A | |
| SCHEMBL12067067 | 0.77 | TNNI3K (0.55) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190119284-A1 | ErbB Inhibitors and Uses Thereof | THE SCRIPPS RESEARCH INSTITUTE | 2019-04-25 | — | — | US | disclosed |
| WO-2017184775-A1 | ERBB INHIBITORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-10-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190119284-A1 | ErbB Inhibitors and Uses Thereof | ERBB3, ERBB2, EGFR | FYN 227/4885HSP90AA1 1026/4885HSP90AB1 491/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.