Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 4/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | LCLAT1 | Q6UWP7 | 1/20 | 0.35 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19475696 | 0.89 | FYN (0.40) | MKNK1EGFRFYNCLK4MEN1 | |
| SCHEMBL19507798 | 0.84 | MKNK1 (0.43) | MKNK1EGFRMEN1KMT2ARAF1 | |
| SCHEMBL19507751 | 0.84 | MKNK1 (0.38) | MKNK1EGFRFYNCLK4MEN1 | |
| SCHEMBL19507750 | 0.82 | MAPT (0.41) | EGFRFYNMEN1MAPK1KMT2A | |
| SCHEMBL19507678 | 0.80 | CLK4 (0.41) | MKNK1FYNCLK4MEN1MAPK1 | |
| SCHEMBL19507728 | 0.78 | LRRK2 (0.37) | MKNK1FYNMAPK1ADORA2A | |
| SCHEMBL19507752 | 0.77 | FYN (0.35) | MKNK1FYNMEN1TP53NFKB1 | |
| SCHEMBL19507682 | 0.77 | MAPT (0.41) | EGFRMEN1TP53MAPK1KMT2A | |
| SCHEMBL29168733 | 0.75 | EGFR (0.54) | EGFRMAPK1 | |
| SCHEMBL30820451 | 0.75 | EGFR (0.54) | EGFRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017184775-A1 | ERBB INHIBITORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-10-26 | — | — | WO | disclosed |