Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.33 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 12/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28378739 | 0.99 | KDM4E (0.38) | KDM4EALDH1A1SMN1; SMN2SIGMAR1LMNA | |
| Hydrochloric Acid SCHEMBL28378737 | 0.99 | KDM4E (0.38) | KDM4EALDH1A1SMN1; SMN2SIGMAR1LMNA | |
| Hydrochloric Acid SCHEMBL30361735 | 0.99 | KDM4E (0.38) | KDM4EALDH1A1SMN1; SMN2SIGMAR1LMNA | |
| SCHEMBL19203407 | 0.85 | KDM4E (0.41) | KDM4EALDH1A1SMN1; SMN2PCSK9BCDIN3D | |
| SCHEMBL30658431 | 0.85 | KDM4E (0.41) | KDM4EALDH1A1SMN1; SMN2PCSK9BCDIN3D | |
| SCHEMBL19203405 | 0.85 | KDM4E (0.41) | KDM4EALDH1A1SMN1; SMN2PCSK9BCDIN3D | |
| SCHEMBL20715568 | 0.78 | KDM4E (0.40) | KDM4EALDH1A1SMN1; SMN2PCSK9BCDIN3D | |
| SCHEMBL20702038 | 0.74 | HCAR3 (0.43) | KDM4EALDH1A1SMN1; SMN2PCSK9HCRTR1 | |
| SCHEMBL19480704 | 0.73 | SIGMAR1 (0.35) | SIGMAR1LMNAMAPTADRA2CHTR2A | |
| SCHEMBL19480711 | 0.73 | SIGMAR1 (0.35) | SIGMAR1LMNAMAPTADRA2CHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11236072-B2 | N-[(pyrimidinylamino)propanyl]-,n-[pyridylamino)propanyl]- and n-[(pyrazinylaminol)propanyl]arylcarboxamides | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2022-02-01 | — | — | US | disclosed |
| EP-3661928-B1 | N-[(PYRIMIDINYLAMINO)PROPANYL]-, N-[(PYRIDYLAMINO)PROPANYL]- AND N-[(PYRAZINYLAMINO)PROPANYL]ARYLCARBOXAMIDES | BOEHRINGER INGELHEIM INT (DE) | 2021-06-16 | — | — | EP | disclosed |
| EP-3442966-B1 | NOVEL N-[(PYRIMIDINYLAMINO)PROPANYL]- AND N-[(PYRIDINYLAMINO)PROPANYL]ARYLCARBOXAMIDES | BOEHRINGER INGELHEIM INT (DE) | 2020-10-14 | — | — | EP | disclosed |
| US-20200231575-A1 | NOVEL N-[(PYRIMIDINYLAMINO)PROPANYL]-,N-[PYRIDYLAMINO)PROPANYL]- AND N-[(PYRAZINYLAMINOL)PROPANYL]ARYLCARBOXAMIDES | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2020-07-23 | — | — | US | disclosed |
| US-10710984-B2 | N-[(Pyrimidinylamino)propanyl]-and N-[(Pyridinylamino)-propanyl]arylcarboxamides | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2020-07-14 | — | — | US | disclosed |
| EP-3442964-B1 | NOVEL N-[(PYRIMIDINYLAMINO)PROPANYL]-AND N [(PYRAZINYLAMINO)PROPANYL]ARYLCARBOXAMIDES | BOEHRINGER INGELHEIM INT (DE) | 2020-05-06 | — | — | EP | disclosed |
| US-20190112297-A1 | Novel N-[(Pyrimidinylamino)Propanyl]-and N-[(Pyridinylamino)Propanyl]Arylcarboxamides | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2019-04-18 | — | — | US | disclosed |
| WO-2019025275-A1 | NOVEL N-[(PYRIMIDINYLAMINO)PROPANYL]-, N-[(PYRIDYLAMINO)PROPANYL] - AND N-[(PYRAZINYLAMINO)PROPANYL]ARYLCARBOXAMIDES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2019-02-07 | — | — | WO | disclosed |
| US-9884854-B2 | N-[(pyrimidinylamino)propanyl]-and N[(pyrazinylamino)proppanyl]arylcarboxamides | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2018-02-06 | — | — | US | disclosed |
| WO-2017178343-A1 | NOVEL N-[(PYRIMIDINYLAMINO)PROPANYL]-AND N-[(PYRIDINYLAMINO)PROPANYL]ARYLCARBOXAMIDES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-10-19 | — | — | WO | disclosed |
| US-20170298053-A1 | NOVEL N-[(PYRIMIDINYLAMINO)PROPANYL]-AND N [(PYRAZINYLAMINO)PROPANYL]ARYLCARBOXAMIDES | BOEHRINGER INGELHEIM INTERNATIONAL GHBH (DE) | 2017-10-19 | — | — | US | disclosed |
| WO-2017178341-A1 | NOVEL N-[(PYRIMIDINYLAMINO)PROPANYL]-AND N [(PYRAZINYLAMINO)PROPANYL]ARYLCARBOXAMIDES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-10-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190112297-A1 | Novel N-[(Pyrimidinylamino)Propanyl]-and N-[(Pyridinylamino)Propanyl]Arylcarboxamides | HCRTR1, HCRTR2, CNR1 | KDM4E 1782/4885ALDH1A1 750/4885SMN1; SMN2 1005/4885 |
| US-10710984-B2 | N-[(Pyrimidinylamino)propanyl]-and N-[(Pyridinylamino)-propanyl]arylcarboxamides | HCRTR1, HCRTR2, CNR1 | KDM4E 1990/4885ALDH1A1 710/4885SMN1; SMN2 842/4885 |
| US-20200231575-A1 | NOVEL N-[(PYRIMIDINYLAMINO)PROPANYL]-,N-[PYRIDYLAMINO)PROPANYL]- AND N-[(PYRAZINYLAMINOL)PROPANYL]ARYLCARBOXAMIDES | HCRTR2, HCRTR1, CNR1 | KDM4E 2043/4885ALDH1A1 809/4885SMN1; SMN2 1638/4885 |
| US-11236072-B2 | N-[(pyrimidinylamino)propanyl]-,n-[pyridylamino)propanyl]- and n-[(pyrazinylaminol)propanyl]arylcarboxamides | HCRTR2, HCRTR1, CNR1 | KDM4E 2339/4885ALDH1A1 748/4885SMN1; SMN2 1129/4885 |
| US-20170298053-A1 | NOVEL N-[(PYRIMIDINYLAMINO)PROPANYL]-AND N [(PYRAZINYLAMINO)PROPANYL]ARYLCARBOXAMIDES | HCRTR2, HCRTR1, CNR1 | KDM4E 2400/4885ALDH1A1 1059/4885SMN1; SMN2 1180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.