Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 4/20 | 0.47 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.42 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 3/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16580037 | 0.84 | DPP4 (0.41) | DPP4DPP8HSD11B1JAK2SMN1; SMN2 | |
| SCHEMBL19478181 | 0.84 | GRM2 (0.44) | HSD11B1JAK2JAK1SMN1; SMN2CNR1 | |
| SCHEMBL2906434 | 0.75 | HSD11B1 (0.47) | HSD11B1CNR1 | |
| SCHEMBL16580106 | 0.73 | GRM2 (0.40) | JAK2CDC7CDK2 | |
| SCHEMBL26581378 | 0.73 | KDM4E (0.36) | JAK2JAK1HSD17B10 | |
| SCHEMBL16571474 | 0.71 | DPP4 (0.44) | DPP4DPP8HSD11B1F2RL3JAK2 | |
| SCHEMBL26037833 | 0.70 | THRB (0.36) | JAK2HSD17B10 | |
| SCHEMBL13415456 | 0.70 | RXFP1 (0.62) | SMN1; SMN2HSD17B10 | |
| SCHEMBL16580108 | 0.69 | SLC22A12 (0.39) | JAK2CNR1CNR2 | |
| SCHEMBL16571429 | 0.68 | DPP4 (0.41) | DPP4DPP8HSD11B1F2RL3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3044207-B1 | INDOL-CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2017-10-18 | — | — | EP | disclosed |