Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | PLK1 | P53350 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | NAMPT | P43490 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 2/20 | 0.48 |
| ▸ | KDM1A | O60341 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8272807 | 0.89 | PLK1 (0.59) | KMT2ANPC1RAB9ASMN1; SMN2PLK1 | |
| SCHEMBL13754022 | 0.86 | NPC1 (0.66) | KDM4EKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17845249 | 0.86 | NPC1 (0.61) | KDM4EKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL507405 | 0.85 | KDM4E (0.58) | KDM4EKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13766441 | 0.84 | NPC1 (0.69) | KDM4EKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28901208 | 0.84 | KDM4E (0.56) | KDM4EKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5483603 | 0.83 | NAMPT (0.51) | KDM4EKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL24529100 | 0.83 | SMYD3 (0.72) | NPC1RAB9ASMN1; SMN2SMYD3HPGD | |
| SCHEMBL12124399 | 0.83 | HPGD (0.71) | KDM4EKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21489911 | 0.82 | SMYD3 (0.71) | PLK1SMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170298075-A1 | TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS | CTXT PTY. LTD. (AU) | 2017-10-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170298075-A1 | TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS | PRMT5, PRMT1, PRMT3 | KDM4E 61/4885KMT2A 38/4885NPC1 2922/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.