SCHEMBL194844

SCHEMBL194844

CCCC(C(=O)O)P(=O)(OCC)OCC

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 2/20 0.42
CHRM1 P11229 1/20 0.41
AKR1A1 P14550 1/20 0.41
CHRM3 P20309 1/20 0.41
HTR2A P28223 1/20 0.41
HTR2C P28335 1/20 0.41
ADRA1A P35348 1/20 0.41
HRH1 P35367 1/20 0.41
DRD3 P35462 1/20 0.41
SLC6A3 Q01959 1/20 0.41
HDAC1 Q13547 1/20 0.41
HDAC2 Q92769 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
CYP3A4 P08684 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
TSHR P16473 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
FDPS P14324 1/20 0.35
FOLH1 Q04609 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11801523 0.92 POLB (0.43) POLBTDP1CYP3A4CYP2C9CYP2C19
SCHEMBL1903133 0.89 CA2 (0.42) POLBCYP3A4CYP2C9CYP2C19FDPS
SCHEMBL4229201 0.85 GPR84 (0.47) FDPS
SCHEMBL13924959 0.85 GPR84 (0.47) FDPS
SCHEMBL5326687 0.85 GPR84 (0.47) FDPS
SCHEMBL262483 0.83 POLB (0.43) POLBTDP1CYP3A4CYP2C9CYP2C19
SCHEMBL1051880 0.82 POLB (0.53) POLBTDP1CYP3A4CYP2C9CYP2C19
SCHEMBL1533394 0.82 CYP3A4 (0.37) POLBTDP1CYP3A4CYP2C9CYP2C19
SCHEMBL3899260 0.82 CHRM1 (0.43) POLBCHRM1AKR1A1CHRM3HTR2A
SCHEMBL2986780 0.80 CHRM1 (0.35) POLBCHRM1AKR1A1CHRM3HTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6384230-B1 2,6-DIMETHYL-5-((4-ETHOXYPHENYL)-METHOXY)-7-(2-METHYLTHIAZOL-4-YL)HEPTA -2,6-DIENOIC ACID ETHYL ESTER FROM MALIC ACID, WITTIG REACTION WITH 2-METHYL-4-THIAZOLYLMETHYL TRIPHENYL PHOSPHONIUM BROMIDE; INTERMEDIATES FOR EPOTHILONE A OR B SCHERING AKTIENGESELLSCHAFT (DE) 2002-05-07 US claimed
EP-2401276-A1 NITROGEN-CONTAINING FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS BETA AMYLOID PRODUCTION INHIBITORS Eisai R&D Management Co., Ltd. (JP) 2012-01-04 EP disclosed
WO-2010098487-A1 NITROGEN-CONTAINING FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS BETA AMYLOID PRODUCTION INHIBITORS EISAI R&D MANAGEMENT CO., LTD. (JP) 2010-09-02 WO disclosed
CN-1294124-C Benzoxazole compound, process for producing the same and herbicide UBE INDUSTRIES (JP) 2007-01-10 CN disclosed
CN-1444569-A Benzoxazole compound, process for producing the same and herbicide UBE INDUSTRIES (JP) 2003-09-24 CN disclosed
EP-0000833-B1 DERIVATIVES OF PHOSPHONOACYL PROLINES AND THEIR PHARMACEUTICAL USE E.R. Squibb & Sons, Inc. (US) 1981-09-02 EP disclosed
US-4151172-A Phosphonoacyl prolines and related compounds E. R. SQUIBB & SONS, INC. (US) 1979-04-24 US disclosed
EP-0000833-A1 Derivatives of phosphonoacyl prolines and their pharmaceutical use E.R. Squibb & Sons, Inc. (US) 1979-02-21 EP disclosed