Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCAT | P04180 | 7/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18138610 | 0.90 | LCAT (0.76) | LCATSMN1; SMN2LMNAMAPTMEN1 | |
| SCHEMBL18138609 | 0.90 | LCAT (0.76) | LCATSMN1; SMN2LMNAMAPTMEN1 | |
| SCHEMBL18138554 | 0.90 | LCAT (0.76) | LCATSMN1; SMN2LMNAMAPTMEN1 | |
| SCHEMBL19485564 | 0.81 | LCAT (0.62) | LCATMAPT | |
| SCHEMBL19485089 | 0.78 | LCAT (0.50) | LCATSMN1; SMN2LMNAPOLBMAPT | |
| SCHEMBL16648838 | 0.78 | LCAT (0.73) | LCATSMN1; SMN2LMNAMAPTMEN1 | |
| SCHEMBL19485568 | 0.76 | LCAT (0.62) | LCAT | |
| SCHEMBL19485093 | 0.74 | LCAT (0.63) | LCAT | |
| SCHEMBL19485567 | 0.73 | LCAT (0.65) | LCAT | |
| SCHEMBL19485396 | 0.73 | LCAT (0.65) | LCAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9796709-B2 | 5-hydroxy-4-(trifluoromethyl)pyrazolopyridine derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2017-10-24 | — | — | US | disclosed |