Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 5/20 | 0.62 |
| ▸ | RNASE1 | P07998 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | ALB | P02768 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19223593 | 0.91 | TK1 (0.63) | TK1RNASE1LMNATSHRALB | |
| SCHEMBL19223589 | 0.91 | TK1 (0.63) | TK1RNASE1LMNATSHRALB | |
| SCHEMBL19146444 | 0.91 | TK1 (0.63) | TK1RNASE1LMNATSHRALB | |
| SCHEMBL887983 | 0.91 | TK1 (0.67) | TK1RNASE1LMNATSHRALB | |
| SCHEMBL2230026 | 0.91 | TK1 (0.67) | TK1RNASE1LMNATSHRALB | |
| SCHEMBL8428685 | 0.91 | TK1 (0.67) | TK1RNASE1LMNATSHRALB | |
| SCHEMBL14546727 | 0.91 | TK1 (0.67) | TK1RNASE1LMNATSHRALB | |
| SCHEMBL13753602 | 0.90 | TK1 (0.64) | TK1RNASE1LMNATSHRALB | |
| SCHEMBL13745911 | 0.90 | TK1 (0.64) | TK1RNASE1LMNATSHRALB | |
| SCHEMBL19257797 | 0.89 | TK1 (0.54) | TK1RNASE1LMNATSHRALB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10000754-B2 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) | SIRNA THERAPEUTICS, INC. (US) | 2018-06-19 | — | — | US | disclosed |
| US-20170298355-A1 | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC ACID (siNA) | BANK OF AMERICA, N.A. | 2017-10-19 | — | — | US | disclosed |