SCHEMBL8428685

SCHEMBL8428685

Cc1cn([C@H]2CC(OP(=O)(O)O)[C@@H](CO)O2)c(=O)[nH]c1=O

nearest known ligand 0.68

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
TK1 P04183 5/20 0.67
RNASE1 P07998 1/20 0.66
LMNA P02545 2/20 0.62
TSHR P16473 2/20 0.62
ALB P02768 1/20 0.62
PKM P14618 1/20 0.62
BLM P54132 1/20 0.62
PMP22 Q01453 1/20 0.62
CYP2D6 P10635 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14546727 1.00 TK1 (0.67) TK1RNASE1LMNATSHRALB
SCHEMBL887983 1.00 TK1 (0.67) TK1RNASE1LMNATSHRALB
SCHEMBL2230026 1.00 TK1 (0.67) TK1RNASE1LMNATSHRALB
SCHEMBL3037394 0.94 TK1 (0.65) TK1RNASE1LMNATSHRALB
SCHEMBL11910917 0.94 TK1 (0.65) TK1RNASE1LMNATSHRALB
SCHEMBL29391024 0.93 RNASE1 (0.61) TK1RNASE1LMNATSHRALB
SCHEMBL29402962 0.92 TK1 (0.67) TK1RNASE1LMNATSHRALB
SCHEMBL29355784 0.92 TK1 (0.67) TK1RNASE1LMNATSHRALB
SCHEMBL19223589 0.92 TK1 (0.63) TK1RNASE1LMNATSHRALB
SCHEMBL19146444 0.92 TK1 (0.63) TK1RNASE1LMNATSHRALB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5962291-A MONOCLONAL ANTIBODY CAPABLE OF HYDROLYZING A SUBSTRATE; HAS TWO BINDING SITES: ONE FOR FREE METAL ION, ONE FOR SUBSTRATE THE REGENTS OF THE UNIVERSITY OF COLORADO (US) 1999-10-05 US disclosed
US-5932718-A CONTACTING NUCLEOTIDE OR OLIGONUCLEOTIDE HAVING 5' H-PHOSPHONATE DERIVATIVE WITH 5'-O-TRITYL-3'-AMINO-2'-DEOXYRIBONUCLEOSIDE IN PRESENCE OF OXIDIZING AGENT PRODUCING PROTECTED INTERNUCLEOSIDE LINKAGE NORTHWESTERN UNIVERSITY (US) 1999-08-03 US disclosed
US-5648480-A Process for making oligonucleotides having modified internucleoside linkages NORTHWESTERN UNIVERSITY (US) 1997-07-15 US disclosed
US-5646260-A PHOSPHORYLATED OLIGONUCLEOTIDES LETSINGER ROBERT L (US) 1997-07-08 US disclosed
US-5476925-A Antisense agents NORTHWESTERN UNIVERSITY (US) 1995-12-19 US disclosed
EP-0289619-B1 PROCESS FOR SYNTHESIZING OLIGONUCLEOTIDES AND COMPOUNDS FOR FORMING HIGH-MOLECULAR PROTECTIVE GROUP DAICEL CHEM (JP) 1995-08-16 EP disclosed
US-4950745-A Process for synthesis of oligonucleotides and compound for forming polymeric protecting group DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1990-08-21 US disclosed
EP-0289619-A1 PROCESS FOR SYNTHESIZING OLIGONUCLEOTIDES AND COMPOUNDS FOR FORMING HIGH-MOLECULAR PROTECTIVE GROUP DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1988-11-09 EP disclosed