Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMP4 | P12644 | 2/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 7/20 | 0.43 |
| ▸ | KHK | P50053 | 3/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.43 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.43 |
| ▸ | BMPR1B | O00238 | 5/20 | 0.41 |
| ▸ | ACVRL1 | P37023 | 5/20 | 0.41 |
| ▸ | BMPR1A | P36894 | 4/20 | 0.41 |
| ▸ | ACVR1B | P36896 | 4/20 | 0.41 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.41 |
| ▸ | BMPR2 | Q13873 | 2/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.41 |
| ▸ | ACVR2B | Q13705 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19486329 | 0.85 | CHRNA7 (0.44) | KHKMAP4K4KIT | |
| SCHEMBL19486352 | 0.85 | KIT (0.39) | ACVR1KHKTGFBR1MAP4K4KIT | |
| SCHEMBL19486444 | 0.85 | KIT (0.42) | RETMAP4K4KIT | |
| SCHEMBL21679774 | 0.82 | KHK (0.43) | BMP4ACVR1KHKKDRTGFBR1 | |
| SCHEMBL19458948 | 0.81 | TDP1 (0.45) | BMP4ACVR1KHKKDRTGFBR1 | |
| SCHEMBL19462890 | 0.79 | RET (0.45) | BMP4ACVR1KHKKDRTGFBR1 | |
| SCHEMBL19481700 | 0.79 | MAPT (0.47) | ACVR1KHKRET | |
| SCHEMBL19481702 | 0.79 | MAPT (0.44) | BMP4ACVR1KHKKDRTGFBR1 | |
| SCHEMBL19486447 | 0.79 | — | — | |
| SCHEMBL19486470 | 0.79 | KIT (0.36) | RETMAP4K4KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3442977-B1 | INHIBITORS OF ACTIVIN RECEPTOR-LIKE KINASE | BLUEPRINT MEDICINES CORP (US) | 2023-06-28 | — | — | EP | disclosed |
| US-10233186-B2 | Inhibitors of activin receptor-like kinase | BLUEPRINT MEDICINES CORPORATION (US) | 2019-03-19 | — | — | US | disclosed |
| US-20170298069-A1 | INHIBITORS OF ACTIVIN RECEPTOR-LIKE KINASE | BLUEPRINT MEDICINES CORPORATION | 2017-10-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10233186-B2 | Inhibitors of activin receptor-like kinase | ACVR1, ACVR2A, ACVRL1 | BMP4 22/4885ACVR1 1/4885KHK 2328/4885 |
| US-20170298069-A1 | INHIBITORS OF ACTIVIN RECEPTOR-LIKE KINASE | ACVR1, ACVR2A, ACVRL1 | BMP4 21/4885ACVR1 1/4885KHK 2037/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.