Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.41 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.41 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.41 |
| ▸ | ACVR1B | P36896 | 2/20 | 0.41 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | BMP4 | P12644 | 1/20 | 0.40 |
| ▸ | NCF1 | P14598 | 2/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 4/20 | 0.37 |
| ▸ | KHK | P50053 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19482443 | 0.81 | RET (0.41) | RETACVR1BMPR1BBMPR1AACVR1B | |
| SCHEMBL19459259 | 0.80 | LIPG (0.43) | RETACVR1KITBMP4NCF1 | |
| SCHEMBL19486469 | 0.79 | BMP4 (0.46) | RETACVR1BMPR1BBMPR1AACVR1B | |
| SCHEMBL21678301 | 0.79 | KIT (0.38) | RETKIT | |
| SCHEMBL21679943 | 0.78 | KIT (0.40) | RETKITMAP4K4 | |
| SCHEMBL30572725 | 0.78 | RET (0.49) | RETACVR1KITNCF1TGFBR1 | |
| SCHEMBL19459081 | 0.78 | RET (0.41) | RETACVR1KITBMP4NCF1 | |
| SCHEMBL19458941 | 0.77 | KIT (0.37) | RETKITMAP4K4 | |
| SCHEMBL19458940 | 0.77 | ALDH1A1 (0.44) | RETKIT | |
| SCHEMBL19459153 | 0.77 | RET (0.40) | RETACVR1BMPR1BBMPR1AACVR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3442977-A1 | INHIBITORS OF ACTIVIN RECEPTOR-LIKE KINASE | Blueprint Medicines Corporation (US) | 2019-02-20 | — | — | EP | disclosed |
| WO-2017181117-A1 | INHIBITORS OF ACTIVIN RECEPTOR-LIKE KINASE | BLUEPRINT MEDICINES CORPORATION (US) | 2017-10-19 | — | — | WO | disclosed |