Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.34 |
| ▸ | TP53 | P04637 | 6/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.31 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | CKS1B | P61024 | 1/20 | 0.31 |
| ▸ | SKP1 | P63208 | 1/20 | 0.31 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.31 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19488879 | 0.87 | MAPT (0.33) | MAPTTP53SMN1; SMN2THRBKDM4E | |
| SCHEMBL19488331 | 0.86 | KDM4E (0.33) | MAPTTP53SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL19488335 | 0.86 | DHODH (0.32) | MAPTTP53SMN1; SMN2THRBKDM4E | |
| SCHEMBL19488857 | 0.85 | MAPT (0.34) | MAPTTP53SMN1; SMN2THRBKDM4E | |
| SCHEMBL19488884 | 0.82 | ALDH1A1 (0.39) | MAPTTP53SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL19488332 | 0.80 | LMNA (0.42) | MEN1KMT2ANPSR1LMNA | |
| SCHEMBL19488649 | 0.79 | MAPT (0.33) | MAPTTP53SMN1; SMN2THRBKDM4E | |
| SCHEMBL12403413 | 0.78 | PRCP (0.40) | — | |
| SCHEMBL19488324 | 0.77 | KIT (0.33) | MAPTTP53SMN1; SMN2THRB | |
| SCHEMBL19488859 | 0.76 | LMNA (0.48) | KDM4EALDH1A1MEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2601188-B1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-10-18 | — | — | EP | disclosed |