Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.30 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.30 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23229326 | 0.81 | PTPN11 (0.32) | PTPN11 | |
| SCHEMBL23508727 | 0.81 | PTPN11 (0.34) | PTPN11MEN1NPC1RAB9AKMT2A | |
| SCHEMBL22199110 | 0.77 | RECQL (0.36) | — | |
| SCHEMBL30474592 | 0.74 | PRMT5 (0.41) | — | |
| SCHEMBL23208853 | 0.72 | JAK2 (0.33) | — | |
| SCHEMBL23683058 | 0.72 | PTPN11 (0.33) | PTPN11 | |
| SCHEMBL21653695 | 0.72 | PTPN11 (0.35) | PTPN11 | |
| SCHEMBL21631683 | 0.72 | PTPN11 (0.33) | PTPN11 | |
| SCHEMBL21631669 | 0.70 | MEN1 (0.39) | PTPN11MEN1KMT2A | |
| SCHEMBL29993893 | 0.70 | SLC9A1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017178377-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES | UCB BIOPHARMA SPRL (BE) | 2017-10-19 | — | — | WO | disclosed |