Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 13/20 | 0.42 |
| ▸ | SRC | P12931 | 8/20 | 0.40 |
| ▸ | FGR | P09769 | 5/20 | 0.40 |
| ▸ | YES1 | P07947 | 4/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.39 |
| ▸ | FYN | P06241 | 7/20 | 0.39 |
| ▸ | LYN | P07948 | 6/20 | 0.39 |
| ▸ | PTK6 | Q13882 | 5/20 | 0.39 |
| ▸ | HCK | P08631 | 4/20 | 0.39 |
| ▸ | BLK | P51451 | 3/20 | 0.39 |
| ▸ | FRK | P42685 | 2/20 | 0.39 |
| ▸ | MAP2K5 | Q13163 | 3/20 | 0.38 |
| ▸ | FLT3 | P36888 | 4/20 | 0.37 |
| ▸ | LCK | P06239 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15613547 | 0.89 | BTK (0.50) | BTKSRCFGRYES1PIK3CD | |
| SCHEMBL15613553 | 0.85 | SRC (0.56) | BTKSRCFGRYES1FGFR1 | |
| SCHEMBL15613540 | 0.85 | BTK (0.48) | BTKSRCFGRYES1FGFR1 | |
| SCHEMBL15613692 | 0.84 | BTK (0.47) | BTKSRCFGRYES1FGFR1 | |
| SCHEMBL15613548 | 0.84 | BTK (0.57) | BTKSRCFGRYES1PIK3CD | |
| SCHEMBL15613698 | 0.81 | FGFR2 (0.46) | BTKSRCFGRYES1FGFR1 | |
| SCHEMBL15613518 | 0.77 | BTK (0.53) | BTKSRCFGRYES1PIK3CD | |
| SCHEMBL15613510 | 0.76 | NUDT14 (0.63) | BTKSRCPIK3CDPIK3CAPIK3CB | |
| SCHEMBL16886172 | 0.73 | FGFR2 (0.47) | BTKSRCFGRYES1FGFR1 | |
| SCHEMBL15613668 | 0.72 | BTK (0.66) | BTKSRCFGRYES1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9796716-B2 | Selective inhibitors of Tec and Src protein kinase families | PHARMASCIENCE, INC. (CA) | 2017-10-24 | — | — | US | disclosed |