Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOX | P28300 | 1/20 | 0.57 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.57 |
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | PPARA | Q07869 | 2/20 | 0.46 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12093687 | 0.86 | LOXL2 (0.65) | LOXLOXL2PLA2G7GSK3AGSK3B | |
| SCHEMBL14861189 | 0.81 | LOX (0.59) | LOXLOXL2PLA2G7GSK3AGSK3B | |
| SCHEMBL21591576 | 0.81 | LOXL2 (0.69) | LOXLOXL2PLA2G7GSK3AGSK3B | |
| SCHEMBL19304183 | 0.79 | TDP1 (0.43) | PTGS2 | |
| SCHEMBL22166111 | 0.79 | TDP1 (0.43) | PTGS2 | |
| SCHEMBL3442793 | 0.79 | TDP1 (0.43) | PTGS2 | |
| SCHEMBL3413456 | 0.79 | TDP1 (0.43) | PTGS2 | |
| SCHEMBL11798255 | 0.79 | TDP1 (0.46) | PTGS2 | |
| SCHEMBL913250 | 0.79 | TDP1 (0.46) | PTGS2 | |
| SCHEMBL7963811 | 0.79 | TDP1 (0.46) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9796707-B2 | Piperazine derivatives for treating disorders | THE UNIVERSITY OF NOTTINGHAM (GB) | 2017-10-24 | — | — | US | disclosed |