Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOX | P28300 | 1/20 | 0.59 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.59 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.40 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.39 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2497237 | 0.89 | LOXL2 (0.62) | LOXLOXL2GSK3AGSK3BFFAR1 | |
| SCHEMBL21591576 | 0.83 | LOXL2 (0.69) | LOXLOXL2GSK3AGSK3BFFAR1 | |
| SCHEMBL17752 | 0.82 | LOXL2 (0.67) | LOXLOXL2GSK3BFFAR1SLC13A5 | |
| SCHEMBL29841247 | 0.82 | LOXL2 (0.67) | LOXLOXL2GSK3BFFAR1SLC13A5 | |
| SCHEMBL19492384 | 0.81 | LOX (0.57) | LOXLOXL2GSK3AGSK3BPLA2G7 | |
| SCHEMBL12093687 | 0.80 | LOXL2 (0.65) | LOXLOXL2GSK3AGSK3BFFAR1 | |
| SCHEMBL14486857 | 0.79 | LOXL2 (0.62) | LOXLOXL2GSK3AGSK3BFFAR1 | |
| SCHEMBL6218599 | 0.79 | LOXL2 (0.73) | LOXLOXL2FFAR1CYP3A4 | |
| SCHEMBL22336235 | 0.79 | LOXL2 (0.68) | LOXLOXL2GSK3AGSK3BFFAR1 | |
| SCHEMBL31583016 | 0.79 | LOXL2 (0.62) | LOXLOXL2GSK3AGSK3BFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013056015-A1 | ISOINDOLINONE AND PYRROLOPYRIDINONE DERIVATIVES AS AKT INHIBITORS | INCYTE CORPORATION (US) | 2013-04-18 | — | — | WO | disclosed |