Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUCY1B2 | O75343 | 20/20 | 0.78 |
| ▸ | GUCY1A2 | P33402 | 20/20 | 0.78 |
| ▸ | GUCY1A1 | Q02108 | 20/20 | 0.78 |
| ▸ | GUCY1B1 | Q02153 | 20/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19485129 | 0.88 | GUCY1B2 (0.93) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL17614803 | 0.88 | GUCY1B2 (1.00) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL17614794 | 0.85 | GUCY1B2 (0.71) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL17614812 | 0.83 | GUCY1B2 (0.74) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL17614792 | 0.83 | GUCY1B2 (0.73) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL17614778 | 0.82 | GUCY1B2 (0.75) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL17614789 | 0.82 | GUCY1B2 (0.80) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL30513569 | 0.82 | GUCY1B2 (1.00) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL15087456 | 0.82 | GUCY1B2 (1.00) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL17614798 | 0.81 | GUCY1B2 (0.79) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170298055-A1 | sGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2017-10-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170298055-A1 | sGC STIMULATORS | GUCY1B1, GUCY1A1, PRKG2 | GUCY1B2 5/4885GUCY1A2 6/4885GUCY1A1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.