PRKG2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL363119	0.44	5/20
SCHEMBL1389878	0.44	5/20
SCHEMBL363855	0.36	5/20
SCHEMBL364346	0.36	5/20
SCHEMBL1389692	0.36	5/20
SCHEMBL1389694	0.36	5/20
SCHEMBL1389695	0.36	5/20
SCHEMBL1230376	0.53	4/20
SCHEMBL1016615	0.50	4/20
SCHEMBL1228234	0.48	4/20
SCHEMBL1390378	0.44	4/20
SCHEMBL1390380	0.44	4/20
SCHEMBL363116	0.39	4/20
SCHEMBL369534	0.39	4/20
SCHEMBL369535	0.39	4/20
SCHEMBL361993	0.38	4/20
SCHEMBL1389598	0.38	4/20
SCHEMBL362642	0.37	4/20
SCHEMBL363842	0.37	4/20
SCHEMBL369687	0.37	4/20

Clinical trials — most relevant to PRKG2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
L-arginine Treatment in Mild Hypertension	PHASE4	UNKNOWN
Switching of Sildenafil to Riociguat in CTEPH Patients	PHASE4	RECRUITING
Precise Endoscopic Application of Nitroglycerin in Preventing Post-ERCP Pancreatitis	PHASE4	RECRUITING
Bosentan in Treatment of Pulmonary Arterial Hypertension	PHASE4	COMPLETED
Cardiovascular Effects of Chronic Sildenafil in Men With Type 2 Diabetes	PHASE4	COMPLETED
Genetic Factors of Erectile Dysfunction Degree and Response to Tadalafil Treatment in Patients With Diabetes	PHASE3	RECRUITING
A Trial of Tadalafil in Interstitial Lung Disease of Scleroderma	PHASE3	COMPLETED
Use of Sildenafil Citrate in Management of Mild Pre-eclampsia	PHASE2/PHASE3	UNKNOWN
Chronic Sildenafil Treatment in Heart Failure	PHASE3	COMPLETED
Low Dose Versus High Dose Methylene Blue in Septic Patients	PHASE2/PHASE3	COMPLETED
Perfusion by Arterial Spin Labelling Following Single Dose Tadalafil in Small Vessel Disease (PASTIS) Trial	PHASE2	COMPLETED
The Phosphodiesterase 4 Inhibitor Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients	PHASE1/PHASE2	WITHDRAWN
Theophylline Treatment for Pseudohypoparathyroidism - Children 2-12 Years Old	PHASE2	ACTIVE_NOT_RECRUITING
Safety Study of Sildenafil in Treatment of Cerebral Aneurysm Vasospasm	PHASE2	WITHDRAWN
Pentoxifylline as an Adjunctive in Treatment of Negative Symptoms in Chronic Schizophrenia	PHASE1/PHASE2	COMPLETED
The Controlled Trial of Apremilast for Rheumatoid Arthritis Treatment (CARAT)	PHASE2	COMPLETED
Tadalafil for Pulmonary Hypertension Due to Chronic Lung Disease	PHASE2	COMPLETED
PKC412 and 5-Azacytidine	PHASE1/PHASE2	COMPLETED
Effect of Modulating the nNOS System on Cardiac, Muscular and Cognitive Function in Becker Muscular Dystrophy Patients	PHASE2	COMPLETED
Effects of Roflumilast on Insulin and Blood Sugar Levels in Prediabetic Overweight and Obese Individuals	PHASE1/PHASE2	COMPLETED
Metformin's Effect on Glucagon-induced Glucose Production and Protein Metabolism.	PHASE1	COMPLETED
Vitamin D Versus Sildenafil Citrate in Fetal Growth Restriction	PHASE1	COMPLETED
Proof of Principle Study for an Efficacy Trial of Linaclotide for Cystic Fibrosis	EARLY_PHASE1	RECRUITING
Intravenous Terbutaline in Severe Status Asthmaticus	nan	UNKNOWN
Role of Nitric Oxide in Diabetic Patients With Erectile Dysfunction	nan	COMPLETED
The Phosphodiesterase-3 Inhibitor Cilostazol as an Adjunctive to Antidepressants in Patients With Major Depressive Disorder.	nan	COMPLETED
Evaluation the Topical Apremilast Nanoformulation in Treatment of Localized Plaque Psoriasis	nan	NOT_YET_RECRUITING
Silodosin, Tadalafil Alone vs. Silodosin Plus Tadalafil as MET for Lower Ureteric Stones	nan	COMPLETED
Ischemic Preconditioning to Prevent Acute Kidney Injury	nan	COMPLETED
ADRB3, ROCK2 and GEF Levels in Overactive Bladder Patients	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a PRKG2 binder may also engage these)

Protein	Name	Similarity
Q64595	—	0.999	Q64595 →
Q61410	—	0.997	Q61410 →
Q03042	—	0.992	Q03042 →
A8X6H1	—	0.990	A8X6H1 →
O76360	—	0.988	O76360 →
Q16974	—	0.977	Q16974 →
PRKCA	Protein kinase C alpha type	0.977	landscape →
PRKCB	Protein kinase C beta type	0.976	landscape →
P05696	—	0.975	P05696 →
P04409	—	0.974	P04409 →
A8KBH6	—	0.974	A8KBH6 →
P10102	—	0.973	P10102 →
P50545	—	0.973	P50545 →
Q6U1I9	—	0.973	Q6U1I9 →
Q8MMZ7	—	0.972	Q8MMZ7 →
P20444	—	0.972	P20444 →
P05130	—	0.971	P05130 →
P81900	—	0.971	P81900 →
Q8I719	—	0.971	Q8I719 →
Q9WVC6	—	0.971	Q9WVC6 →
Q17941	—	0.970	Q17941 →
HCK	Tyrosine-protein kinase HCK	0.970	landscape →
FYN	Tyrosine-protein kinase Fyn	0.970	landscape →
P90980	—	0.970	P90980 →
W7JX98	—	0.970	W7JX98 →
P21137	—	0.970	P21137 →
P68404	—	0.970	P68404 →
P05772	—	0.970	P05772 →
Q9ERE3	—	0.969	Q9ERE3 →
P05126	—	0.969	P05126 →