Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 8/20 | 0.48 |
| ▸ | ADH5 | P11766 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19494371 | 0.86 | TBXAS1 (0.49) | TBXAS1POLBKMT2AGSK3B | |
| SCHEMBL19468300 | 0.85 | HTT (0.50) | TBXAS1LMNAGSK3BALDH1A1HPGD | |
| SCHEMBL165635 | 0.84 | CA12 (0.45) | TBXAS1POLBCYP19A1 | |
| SCHEMBL19494534 | 0.83 | CYP11B1 (0.42) | CYP19A1ALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL19468030 | 0.82 | CYP11B1 (0.49) | MEN1KMT2ACYP19A1 | |
| SCHEMBL19468243 | 0.82 | CYP19A1 (0.46) | POLBMEN1KMT2ACYP19A1HPGD | |
| SCHEMBL19494224 | 0.81 | FAAH (0.33) | TBXAS1CYP19A1ALDH1A1HDAC3HDAC4 | |
| SCHEMBL19468195 | 0.79 | CYP19A1 (0.52) | POLBKMT2ACYP19A1ALDH1A1GFER | |
| SCHEMBL19468023 | 0.79 | TP53 (0.40) | TBXAS1CYP19A1 | |
| SCHEMBL19494536 | 0.78 | GFER (0.40) | LMNAMEN1KMT2ACYP19A1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3235815-A1 | AGENTS AGAINST PARASITIC HELMINTHS | PHILIPPS-UNIVERSITÄT MARBURG (DE) | 2017-10-25 | — | — | EP | disclosed |