Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 16/20 | 0.55 |
| ▸ | JAK3 | P52333 | 3/20 | 0.55 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.42 |
| ▸ | JAK1 | P23458 | 2/20 | 0.39 |
| ▸ | TYK2 | P29597 | 2/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19494932 | 0.79 | IKBKB (0.43) | JAK2 | |
| SCHEMBL16338034 | 0.78 | CFTR (0.58) | JAK2JAK3CDK5CDK5R1 | |
| SCHEMBL16263935 | 0.76 | JAK2 (0.42) | JAK2 | |
| SCHEMBL3512122 | 0.72 | JAK2 (1.00) | JAK2JAK3 | |
| SCHEMBL19494741 | 0.71 | CFTR (0.49) | JAK2 | |
| SCHEMBL19494397 | 0.71 | CFTR (0.44) | JAK2 | |
| SCHEMBL19494662 | 0.71 | TYK2 (0.44) | JAK2TYK2 | |
| SCHEMBL19494315 | 0.69 | NPC1 (0.43) | JAK2JAK3 | |
| SCHEMBL3510016 | 0.67 | JAK2 (0.64) | JAK2JAK3 | |
| SCHEMBL19494743 | 0.67 | CHEK1 (0.39) | JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2994463-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF CYSTIC FIBROSIS | GALAPAGOS NV (BE) | 2017-10-25 | — | — | EP | disclosed |