Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.38 |
| ▸ | CFTR | P13569 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19494883 | 0.83 | CFTR (0.45) | CFTRALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL19494715 | 0.82 | CFTR (0.38) | MAPK8CFTRALDH1A1MAPTMEN1 | |
| SCHEMBL16246336 | 0.82 | CFTR (0.49) | MAPK8CFTRALDH1A1MAPTMEN1 | |
| SCHEMBL19494339 | 0.81 | MAPT (0.38) | CFTRALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL19494641 | 0.81 | CFTR (0.37) | MAPK8CFTRALDH1A1MAPTMEN1 | |
| SCHEMBL19494909 | 0.79 | MAPT (0.37) | CFTRALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL19494512 | 0.77 | IKBKB (0.41) | CFTRALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL16263744 | 0.72 | CFTR (0.58) | CFTRMEN1KMT2AJAK2IKBKB | |
| SCHEMBL16246328 | 0.71 | CFTR (0.47) | CFTRALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL16387385 | 0.71 | KDM4E (0.43) | CFTRALDH1A1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2994463-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF CYSTIC FIBROSIS | GALAPAGOS NV (BE) | 2017-10-25 | — | — | EP | disclosed |