Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.45 |
| ▸ | IKBKB | O14920 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19494715 | 0.92 | CFTR (0.38) | CFTRIKBKBALDH1A1KDM4EHPGD | |
| SCHEMBL19494641 | 0.89 | CFTR (0.37) | CFTRALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL19494339 | 0.85 | MAPT (0.38) | CFTRALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL16387385 | 0.84 | KDM4E (0.43) | CFTRIKBKBALDH1A1KDM4EHPGD | |
| SCHEMBL19494538 | 0.83 | MAPK8 (0.38) | CFTRIKBKBALDH1A1KDM4EHPGD | |
| SCHEMBL19494909 | 0.82 | MAPT (0.37) | CFTRALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL16263654 | 0.81 | CFTR (0.69) | CFTRIKBKBALDH1A1KDM4EHPGD | |
| SCHEMBL19494341 | 0.80 | IKBKB (0.42) | CFTRIKBKBALDH1A1KDM4EHPGD | |
| SCHEMBL19494408 | 0.75 | KDM4E (0.47) | CFTRALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL16246383 | 0.73 | CFTR (0.59) | CFTRALDH1A1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2994463-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF CYSTIC FIBROSIS | GALAPAGOS NV (BE) | 2017-10-25 | — | — | EP | disclosed |