Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 5/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | IKBKB | O14920 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19494883 | 0.92 | CFTR (0.45) | CFTRCHEK1ALDH1A1MAPTALOX15 | |
| SCHEMBL19494641 | 0.90 | CFTR (0.37) | CFTRCHEK1ALDH1A1MAPTALOX15 | |
| SCHEMBL19494339 | 0.84 | MAPT (0.38) | CFTRCHEK1ALDH1A1MAPTALOX15 | |
| SCHEMBL19494538 | 0.82 | MAPK8 (0.38) | CFTRALDH1A1MAPTALOX15HSD17B10 | |
| SCHEMBL19494909 | 0.82 | MAPT (0.37) | CFTRCHEK1ALDH1A1MAPTALOX15 | |
| SCHEMBL16246383 | 0.81 | CFTR (0.59) | CFTRCHEK1ALDH1A1MAPTALOX15 | |
| SCHEMBL16387385 | 0.75 | KDM4E (0.43) | CFTRALDH1A1MAPTALOX15HSD17B10 | |
| SCHEMBL16263744 | 0.73 | CFTR (0.58) | CFTRCHEK1MEN1KMT2AIKBKB | |
| SCHEMBL16246368 | 0.73 | CFTR (0.58) | CFTRCHEK1ALDH1A1MAPTMEN1 | |
| SCHEMBL16263654 | 0.73 | CFTR (0.69) | CFTRALDH1A1MAPTALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2994463-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF CYSTIC FIBROSIS | GALAPAGOS NV (BE) | 2017-10-25 | — | — | EP | disclosed |