Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | CFTR | P13569 | 4/20 | 0.42 |
| ▸ | IKBKB | O14920 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16338476 | 0.79 | CFTR (0.62) | TYK2CFTRIKBKBMEN1JAK2 | |
| SCHEMBL19494512 | 0.78 | IKBKB (0.41) | CFTRIKBKBMEN1JAK2EIF2AK2 | |
| SCHEMBL19494662 | 0.78 | TYK2 (0.44) | TYK2CFTRIKBKBMEN1JAK2 | |
| SCHEMBL19494900 | 0.77 | NPC1 (0.47) | IKBKBMEN1JAK2KMT2ATDP1 | |
| SCHEMBL19494413 | 0.77 | IKBKB (0.46) | CFTRIKBKBMEN1JAK2EIF2AK2 | |
| SCHEMBL19494934 | 0.76 | KMT2A (0.41) | CFTRIKBKBMEN1JAK2EIF2AK2 | |
| SCHEMBL19494898 | 0.75 | JAK2 (0.45) | CFTRIKBKBMEN1JAK2EIF2AK2 | |
| SCHEMBL19494396 | 0.74 | CFTR (0.43) | CFTRIKBKBMEN1JAK2EIF2AK2 | |
| SCHEMBL19494442 | 0.73 | MEN1 (0.42) | CFTRIKBKBMEN1JAK2EIF2AK2 | |
| SCHEMBL19494938 | 0.72 | MEN1 (0.41) | CFTRIKBKBMEN1JAK2EIF2AK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2994463-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF CYSTIC FIBROSIS | GALAPAGOS NV (BE) | 2017-10-25 | — | — | EP | disclosed |