Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | IKBKB | O14920 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 3/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19494512 | 0.80 | IKBKB (0.41) | KMT2ATDP1IKBKBMEN1JAK2 | |
| SCHEMBL16246522 | 0.79 | CFTR (0.65) | KMT2ATDP1IKBKBMEN1JAK2 | |
| SCHEMBL19494413 | 0.77 | IKBKB (0.46) | KMT2ATDP1IKBKBMEN1JAK2 | |
| SCHEMBL19494660 | 0.76 | TYK2 (0.46) | KMT2ATDP1IKBKBMEN1JAK2 | |
| SCHEMBL19494898 | 0.75 | JAK2 (0.45) | KMT2ATDP1IKBKBMEN1JAK2 | |
| SCHEMBL19494396 | 0.74 | CFTR (0.43) | KMT2ATDP1IKBKBMEN1JAK2 | |
| SCHEMBL19494442 | 0.73 | MEN1 (0.42) | KMT2ATDP1IKBKBMEN1JAK2 | |
| SCHEMBL19494900 | 0.73 | NPC1 (0.47) | KMT2ATDP1IKBKBMEN1JAK2 | |
| SCHEMBL19494938 | 0.72 | MEN1 (0.41) | KMT2ATDP1IKBKBMEN1JAK2 | |
| SCHEMBL19494384 | 0.69 | CFTR (0.54) | KMT2ATDP1IKBKBMEN1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2994463-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF CYSTIC FIBROSIS | GALAPAGOS NV (BE) | 2017-10-25 | — | — | EP | disclosed |