Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | GALK1 | P51570 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19494386 | 0.77 | CFTR (0.39) | RAB9AALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL19494401 | 0.77 | CFTR (0.46) | RAB9AALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL16261379 | 0.76 | CFTR (0.64) | MMP1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL19494695 | 0.73 | MAPK1 (0.41) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL7003497 | 0.71 | MAPK1 (0.52) | RAB9AALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL19494416 | 0.70 | CNR1 (0.45) | RAB9AALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL6505096 | 0.69 | IKBKB (0.47) | RAB9AALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL19494313 | 0.67 | IKBKB (0.32) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL19494312 | 0.66 | MEN1 (0.32) | MEN1KMT2AMAPTKDM4ECFTR | |
| SCHEMBL16246232 | 0.66 | CFTR (0.58) | RAB9AALDH1A1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2994463-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF CYSTIC FIBROSIS | GALAPAGOS NV (BE) | 2017-10-25 | — | — | EP | disclosed |