Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19494498 | 0.81 | CFTR (0.40) | CFTRCHEK1MAPTKDM4EMEN1 | |
| SCHEMBL19494892 | 0.77 | MMP1 (0.41) | CFTRMAPTKDM4EMEN1KMT2A | |
| SCHEMBL19494401 | 0.77 | CFTR (0.46) | CFTRCHEK1MAPTKDM4EMEN1 | |
| SCHEMBL16338262 | 0.76 | CFTR (0.67) | CFTRCHEK1MAPTKDM4EMEN1 | |
| SCHEMBL16246221 | 0.75 | CFTR (0.65) | CFTRCHEK1MAPTKDM4EMEN1 | |
| SCHEMBL19494618 | 0.74 | HDAC3 (0.44) | CFTRCHEK1MAPTKDM4EMEN1 | |
| SCHEMBL19494686 | 0.74 | MAPK8 (0.49) | CFTRCHEK1MAPTKDM4EMEN1 | |
| SCHEMBL19494477 | 0.73 | MAPT (0.35) | CFTRCHEK1MAPTKDM4EMEN1 | |
| SCHEMBL19494695 | 0.73 | MAPK1 (0.41) | CFTRCHEK1MAPTKDM4EMEN1 | |
| SCHEMBL16337653 | 0.73 | CFTR (0.62) | CFTRCHEK1MAPTKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2994463-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF CYSTIC FIBROSIS | GALAPAGOS NV (BE) | 2017-10-25 | — | — | EP | disclosed |