Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CFTR | P13569 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 6/20 | 0.40 |
| ▸ | HTT | P42858 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19494649 | 0.88 | CFTR (0.43) | KDM4EMAPTCFTRHSD17B10HPGD | |
| SCHEMBL19494912 | 0.78 | CFTR (0.40) | KDM4EMAPTCFTRHSD17B10HPGD | |
| SCHEMBL16246225 | 0.75 | CFTR (0.45) | KDM4EMAPTCFTRHSD17B10HPGD | |
| SCHEMBL2699680 | 0.75 | STAT3 (0.57) | KDM4EMAPTHSD17B10HPGDALDH1A1 | |
| SCHEMBL16246469 | 0.75 | CFTR (0.44) | KDM4EMAPTCFTRHSD17B10HPGD | |
| SCHEMBL16263896 | 0.71 | FLT3 (0.44) | KDM4EMAPTHSD17B10HPGDALDH1A1 | |
| SCHEMBL16338522 | 0.70 | CFTR (0.65) | KDM4EMAPTCFTRMEN1KMT2A | |
| SCHEMBL6999862 | 0.68 | JAK2 (0.64) | IKBKBJAK2JAK3 | |
| SCHEMBL2698761 | 0.68 | NPC1 (0.62) | KDM4EMAPTHSD17B10HPGDALDH1A1 | |
| SCHEMBL19494315 | 0.68 | NPC1 (0.43) | KDM4EMAPTHSD17B10HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2994463-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF CYSTIC FIBROSIS | GALAPAGOS NV (BE) | 2017-10-25 | — | — | EP | disclosed |