Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 3/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16263801 | 0.83 | L3MBTL1 (0.47) | SMN1; SMN2MAPTMEN1KMT2ANPC1 | |
| SCHEMBL16263912 | 0.82 | BCL3 (0.42) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL16263849 | 0.81 | CNR2 (0.42) | ALDH1A1SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL16263934 | 0.81 | MAPT (0.33) | CFTRKDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL19494649 | 0.80 | CFTR (0.43) | CFTRKDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL16263844 | 0.79 | KDM1A (0.36) | KDM1AKDM4ESMN1; SMN2MAPTMEN1 | |
| SCHEMBL16261720 | 0.79 | RAB9A (0.47) | CFTRKDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL19494633 | 0.78 | ALDH1A1 (0.33) | CFTRKDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL19494919 | 0.78 | KDM4E (0.43) | CFTRKDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL16246270 | 0.77 | MAPT (0.54) | CFTRKDM1AKDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2994463-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF CYSTIC FIBROSIS | GALAPAGOS NV (BE) | 2017-10-25 | — | — | EP | disclosed |