Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19494507 | 0.83 | IKBKB (0.40) | IKBKBMEN1KMT2AJAK2 | |
| SCHEMBL19494315 | 0.78 | NPC1 (0.43) | NPC1RAB9AALDH1A1HPGDKDM4E | |
| SCHEMBL16263740 | 0.74 | ALDH1A1 (0.54) | NPC1RAB9AALDH1A1HPGDKDM4E | |
| SCHEMBL19494649 | 0.73 | CFTR (0.43) | NPC1RAB9AALDH1A1HPGDKDM4E | |
| SCHEMBL16263892 | 0.73 | NPC1 (0.42) | NPC1RAB9AALDH1A1HPGDKDM4E | |
| SCHEMBL16263847 | 0.72 | NPC1 (0.42) | NPC1RAB9AALDH1A1HPGDKDM4E | |
| SCHEMBL19494919 | 0.71 | KDM4E (0.43) | NPC1RAB9AALDH1A1HPGDKDM4E | |
| SCHEMBL16337977 | 0.70 | CFTR (0.50) | FLT3NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL7003680 | 0.70 | KDM4E (0.63) | NPC1RAB9AALDH1A1HPGDKDM4E | |
| SCHEMBL19494428 | 0.70 | RORC (0.42) | NPC1RAB9AALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014180562-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF CYSTIC FIBROSIS | GALAPAGOS NV (BE) | 2014-11-13 | — | — | WO | disclosed |