Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CCR4 | P51679 | 3/20 | 0.32 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.31 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.31 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.30 |
| ▸ | TUBB | P07437 | 3/20 | 0.30 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.30 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.30 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.30 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.30 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.30 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL321488 | 0.82 | POLB (0.52) | ENPP2POLBTDP1CA1CA2 | |
| SCHEMBL320788 | 0.78 | APOBEC3A (0.41) | ENPP2CA1CA2ORAI1ORAI2 | |
| SCHEMBL4881938 | 0.77 | ENPP2 (0.34) | ENPP2CA1CA2CYP2C19 | |
| SCHEMBL29927287 | 0.76 | CRHBP (0.38) | ENPP2POLBTDP1CA1CA2 | |
| SCHEMBL31016804 | 0.76 | ENPP2 (0.36) | ENPP2POLBTDP1CA1CA2 | |
| SCHEMBL29956624 | 0.76 | MCHR1 (0.38) | ENPP2POLBTDP1CA1CA2 | |
| SCHEMBL12294984 | 0.76 | CRHBP (0.38) | ENPP2POLBTDP1CA1CA2 | |
| SCHEMBL15010557 | 0.76 | ENPP2 (0.36) | ENPP2POLBTDP1CA1CA2 | |
| SCHEMBL22257074 | 0.75 | POLB (0.36) | POLBTDP1CA1CA2CCR4 | |
| SCHEMBL13696715 | 0.74 | ENPP2 (0.39) | ENPP2CA1CA2ORAI1ORAI2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8754100-B2 | Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitors | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2014-06-17 | — | — | US | disclosed |
| EP-2615090-A1 | Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitors | Eisai R&D Management Co., Ltd. (JP) | 2013-07-17 | — | — | EP | disclosed |
| EP-2401276-B1 | NITROGEN-CONTAINING FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS BETA AMYLOID PRODUCTION INHIBITORS | EISAI R&D MAN CO LTD (JP) | 2013-06-05 | — | — | EP | disclosed |
| US-20120053171-A1 | Nitrogen-Containing Fused Heterocyclic Compounds and Their use as Beta Amyloid Production Inhibitors | EISAI R&D MANAGEMENT CO., LTD., (JP) | 2012-03-01 | — | — | US | disclosed |
| EP-2401276-A1 | NITROGEN-CONTAINING FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS BETA AMYLOID PRODUCTION INHIBITORS | Eisai R&D Management Co., Ltd. (JP) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010098487-A1 | NITROGEN-CONTAINING FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS BETA AMYLOID PRODUCTION INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053171-A1 | Nitrogen-Containing Fused Heterocyclic Compounds and Their use as Beta Amyloid Production Inhibitors | BACE1, APP, PSEN1 | ENPP2 1743/4885POLB 2700/4885TDP1 924/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.