Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 6/20 | 0.82 |
| ▸ | BRAF | P15056 | 12/20 | 0.69 |
| ▸ | EGFR | P00533 | 10/20 | 0.66 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.62 |
| ▸ | KDR | P35968 | 1/20 | 0.62 |
| ▸ | CSF1R | P07333 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27933497 | 0.91 | KIT (0.84) | KITBRAFEGFRCSF1R | |
| SCHEMBL29493482 | 0.90 | KIT (1.00) | KITBRAFEGFRCSF1R | |
| SCHEMBL30080656 | 0.90 | KIT (1.00) | KITBRAFEGFRCSF1R | |
| SCHEMBL588975 | 0.90 | KIT (1.00) | KITBRAFEGFRCSF1R | |
| SCHEMBL15442316 | 0.90 | KIT (0.81) | KITBRAFEGFRFGFR1KDR | |
| SCHEMBL19500739 | 0.88 | KIT (0.78) | KITBRAFEGFRFGFR1 | |
| SCHEMBL19500734 | 0.88 | KIT (0.78) | KITBRAFEGFR | |
| SCHEMBL18323290 | 0.87 | KIT (0.85) | KITBRAFEGFRFGFR1KDR | |
| SCHEMBL588917 | 0.86 | KIT (0.93) | KITBRAFEGFRCSF1R | |
| SCHEMBL27754292 | 0.86 | KIT (0.75) | KITBRAFEGFRCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10266537-B2 | 3-acetylenyl-pyrazole-pyrimidine derivative, and preparation method therefor and uses thereof | St. Chuan University (CN) | 2019-04-23 | — | — | US | disclosed |
| US-20170305920-A1 | 3-ACETYLENYL-PYRAZOLE-PYRIMIDINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USES THEREOF | SI CHUAN UNIVERSITY (CN) | 2017-10-26 | — | — | US | disclosed |
| US-20170305920-A1 | 3-ACETYLENYL-PYRAZOLE-PYRIMIDINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USES THEREOF | SI CHUAN UNIVERSITY (CN) | 2017-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170305920-A1 | 3-ACETYLENYL-PYRAZOLE-PYRIMIDINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USES THEREOF | DPYD, TYMP, WEE1 | KIT 262/4885BRAF 516/4885EGFR 1904/4885 |
| US-10266537-B2 | 3-acetylenyl-pyrazole-pyrimidine derivative, and preparation method therefor and uses thereof | DPYD, TYMP, WEE1 | KIT 262/4885BRAF 516/4885EGFR 1904/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.