Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | USP14 | P54578 | 15/20 | 0.50 |
| ▸ | USP7 | Q93009 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | USP5 | P45974 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6921647 | 0.91 | USP14 (0.62) | SMN1; SMN2HPGDUSP14USP7 | |
| SCHEMBL6923922 | 0.91 | SMN1; SMN2 (0.52) | SMN1; SMN2HPGDUSP14USP7KDM4E | |
| SCHEMBL14708800 | 0.89 | SMN1; SMN2 (0.50) | SMN1; SMN2HPGDUSP14USP7KDM4E | |
| SCHEMBL16079020 | 0.76 | SMN1; SMN2 (1.00) | SMN1; SMN2HPGDUSP14USP7KDM4E | |
| SCHEMBL5365241 | 0.75 | CNR1 (0.68) | USP14USP7 | |
| SCHEMBL6922583 | 0.75 | SMN1; SMN2 (0.97) | SMN1; SMN2HPGDUSP14USP7KDM4E | |
| SCHEMBL21484690 | 0.73 | SMN1; SMN2 (0.60) | SMN1; SMN2HPGDUSP14USP7KDM4E | |
| SCHEMBL16729187 | 0.73 | USP14 (0.83) | USP14 | |
| SCHEMBL4936082 | 0.72 | MEN1 (0.75) | SMN1; SMN2HPGDNPC1SLC6A4 | |
| SCHEMBL16729189 | 0.71 | USP14 (0.83) | USP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9849135-B2 | USP14 inhibitors for treating or preventing viral infections | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-12-26 | — | — | US | disclosed |
| EP-2528911-B1 | COMPOSITIONS AND METHODS FOR ENHANCING PROTEASOME ACTIVITY | HARVARD COLLEGE (US) | 2017-10-25 | — | — | EP | disclosed |