Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CCND1 | P24385 | 6/20 | 0.43 |
| ▸ | CDK4 | P11802 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 5/20 | 0.43 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.42 |
| ▸ | CCND3 | P30281 | 1/20 | 0.42 |
| ▸ | WNT3A | P56704 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitric Acid SCHEMBL19468605 | 0.92 | FGFR3 (0.42) | FGFR3ALDH1A1CCND1CDK4RAB9A | |
| SCHEMBL22544380 | 0.86 | FGFR3 (0.44) | FGFR3ALDH1A1CCND1CDK4RAB9A | |
| SCHEMBL29557854 | 0.83 | WNT3A (0.52) | CCND1CDK4RAB9ANPC1CDK6 | |
| SCHEMBL20037430 | 0.80 | ALDH1A1 (0.51) | ALDH1A1CCND1CDK4RAB9ANPC1 | |
| SCHEMBL1126359 | 0.77 | NAMPT (0.50) | FGFR3ALDH1A1RAB9ANPC1TP53 | |
| SCHEMBL28390145 | 0.76 | ALDH1A1 (0.53) | ALDH1A1RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL3314013 | 0.75 | KMT2A (0.50) | ALDH1A1RAB9ANPC1TP53POLB | |
| Trifluoroacetic Acid SCHEMBL18453950 | 0.74 | WNT3A (0.49) | CCND1CDK4RAB9ANPC1WNT3A | |
| SCHEMBL1126048 | 0.74 | ALDH1A1 (0.54) | ALDH1A1RAB9ANPC1TP53POLB | |
| SCHEMBL2233359 | 0.74 | ALDH1A1 (0.54) | ALDH1A1CCND1CDK4RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118307517-A | Preparation method of arbeli and intermediate thereof | 北京海美源医药科技有限公司 | 2024-07-09 | — | — | CN | disclosed |
| US-9969718-B2 | Preparation method for Bemaciclb | SUZHOU MIRACPHARMA TECHNOLOGY CO., LTD. (CN) | 2018-05-15 | — | — | US | disclosed |
| WO-2018045957-A1 | CDK4/6 INHIBITOR AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 江苏豪森药业集团有限公司 | 2018-03-15 | — | — | WO | disclosed |
| US-20170305884-A1 | PREPARATION METHOD FOR BEMACICLB | SUZHOU MIRACPHARMA TECHNOLOGY CO., LTD. (CN) | 2017-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170305884-A1 | PREPARATION METHOD FOR BEMACICLB | GMPS, GUCY1B2, NUP188 | FGFR3 527/4885ALDH1A1 2819/4885CCND1 1292/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.