Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | NPC1 | O15118 | 2/20 | 0.65 |
| ▸ | RAB9A | P51151 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.55 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.55 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | HTR1D | P28221 | 1/20 | 0.50 |
| ▸ | HTR1B | P28222 | 1/20 | 0.50 |
| ▸ | HTR1F | P30939 | 1/20 | 0.50 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1948508 | 0.90 | SMN1; SMN2 (0.80) | TP53SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL14590655 | 0.82 | NOTUM (0.61) | TP53SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL5793078 | 0.80 | NOTUM (1.00) | TP53SMN1; SMN2NOTUMLMNAHSD17B3 | |
| SCHEMBL5795715 | 0.80 | NOTUM (1.00) | TP53SMN1; SMN2NOTUMLMNAHSD17B3 | |
| SCHEMBL29119375 | 0.80 | TP53 (0.57) | TP53NPC1RAB9ANOTUMLMNA | |
| SCHEMBL30655691 | 0.80 | TP53 (0.57) | TP53NPC1RAB9ANOTUMLMNA | |
| SCHEMBL14871647 | 0.80 | TMPRSS2 (0.76) | TP53SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL1950239 | 0.80 | NOTUM (0.64) | TP53MAPTNOTUMLMNAHSD17B3 | |
| SCHEMBL4425080 | 0.79 | CREBBP (0.80) | TP53RAB9ALMNAHSD17B3CREBBP | |
| SCHEMBL14067238 | 0.78 | NOTUM (0.57) | TP53SMN1; SMN2NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438055-B1 | DIHYDROINDOLE AND TETRAHYDROISOQUINOLINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL INHIBITORS | JAPAN TOBACCO INC (JP) | 2018-10-24 | — | — | EP | claimed |
| US-8426442-B2 | Compounds | XENTION LTD (GB) | 2013-04-23 | — | — | US | claimed |
| EP-2438055-B1 | DIHYDROINDOLE AND TETRAHYDROISOQUINOLINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL INHIBITORS | JAPAN TOBACCO INC (JP) | 2018-10-24 | — | — | EP | disclosed |
| US-8426442-B2 | Compounds | XENTION LTD (GB) | 2013-04-23 | — | — | US | disclosed |
| US-20110136860-A1 | Compounds | XENTION LTD. (GB) | 2011-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110136860-A1 | Compounds | NR3C2, NR5A1, NR0B2 | TP53 4557/4885SMN1; SMN2 2483/4885NPC1 418/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.